STRINGSTRING
LECT2 LECT2 CAMK2A CAMK2A NTSR1 NTSR1 RIMS4 RIMS4 AGRP AGRP STRA6 STRA6 NR5A1 NR5A1 GH GH COL4A6 COL4A6 MAPK9 MAPK9 POU3F1 POU3F1 NFATC1 NFATC1 ACTA2 ACTA2 ITGA8 ITGA8 TCF7 TCF7 CRYM CRYM POMC POMC FABP7 FABP7 CEBPD CEBPD MAPK10 MAPK10 SV2B SV2B CNTNAP2 CNTNAP2 ALDH1A3 ALDH1A3 GAD1 GAD1 MECOM MECOM IGF2 IGF2 GBX1 GBX1 TBX3 TBX3 IGFBP7 IGFBP7 RPL4 RPL4 CAV1 CAV1 SYNJ1 SYNJ1 SREBF1 SREBF1 FOS FOS NTS NTS ACE ACE WNT6 WNT6 SIX6 SIX6 LAMA1 LAMA1 SV2C SV2C NMU NMU GRM5 GRM5 SLC5A7 SLC5A7 OTOF OTOF SYTL5 SYTL5 CHRNB3 CHRNB3 ALDH1A1 ALDH1A1 RAB3C RAB3C PIK3C2G PIK3C2G PMCH PMCH BMP4 BMP4 TGFBR2 TGFBR2 THRB THRB NPY NPY ASB2 ASB2 TIPARP TIPARP TRHDE TRHDE TRH TRH GHRL GHRL SST SST APOD APOD INS INS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LECT2Myeloid protein 1. (322 aa)
CAMK2AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (489 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (399 aa)
RIMS4Regulating synaptic membrane exocytosis 4. (446 aa)
AGRPAgouti-related protein. (233 aa)
STRA6Uncharacterized protein. (671 aa)
NR5A1Uncharacterized protein. (466 aa)
GHSomatotropin; Growth hormone plays an important role in growth control. (216 aa)
COL4A6Collagen IV NC1 domain-containing protein. (170 aa)
MAPK9Mitogen-activated protein kinase 9; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity (By similarity). May play a role in the development of the central nervous system during embryogenesis. May play a role in the regulation of the circadian clock (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. (424 aa)
POU3F1POU domain protein. (374 aa)
NFATC1Nuclear factor of activated T cells 1. (909 aa)
ACTA2Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (377 aa)
ITGA8Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1, TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis (By similarity). Neuronal receptor for TNC it mediates cell- cell interactions and regulates neurite outgrowth of sensory and motor neurons. (1076 aa)
TCF7HMG box domain-containing protein. (397 aa)
CRYMCrystallin mu. (252 aa)
POMCUncharacterized protein. (251 aa)
FABP7Fatty acid-binding protein, brain; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
CEBPDCCAAT enhancer binding protein delta. (302 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
SV2BSynaptic vesicle glycoprotein 2B. (705 aa)
CNTNAP2Contactin associated protein like 2. (1344 aa)
ALDH1A3Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (512 aa)
GAD1Glutamate decarboxylase 67. (590 aa)
MECOMMDS1 and EVI1 complex locus. (1245 aa)
IGF2Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling. (187 aa)
GBX1Gastrulation brain homeobox 1. (243 aa)
TBX3T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. (732 aa)
IGFBP7Insulin like growth factor binding protein 7. (327 aa)
RPL4Ribos_L4_asso_C domain-containing protein. (390 aa)
CAV1Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa)
SYNJ1Synaptojanin 1. (1536 aa)
SREBF1BHLH domain-containing protein. (1116 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, may activate phospholipid synthesis (By similarity). (367 aa)
NTSNeurotensin. (164 aa)
ACEAngiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. (1281 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
SIX6Homeobox protein SIX6; May be involved in eye development. Belongs to the SIX/Sine oculis homeobox family. (447 aa)
LAMA1Uncharacterized protein. (3091 aa)
SV2CSynaptic vesicle glycoprotein 2C. (727 aa)
NMUNeuromedin-U-25; Stimulates uterine smooth muscle contraction and causes selective vasoconstriction; Belongs to the NmU family. (181 aa)
GRM5G_PROTEIN_RECEP_F3_4 domain-containing protein. (1242 aa)
SLC5A7Uncharacterized protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (578 aa)
OTOFOtoferlin. (1810 aa)
SYTL5Synaptotagmin like 5. (764 aa)
CHRNB3Neuronal acetylcholine receptor subunit beta-3; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-3/CHRNB3 sub- subfamily. (455 aa)
ALDH1A1Retinal dehydrogenase 1; Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (By similarity). (509 aa)
RAB3CRAB3C, member RAS oncogene family. (227 aa)
PIK3C2GPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1478 aa)
PMCHPMCH. (163 aa)
BMP4Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. (404 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (671 aa)
THRBThyroid hormone receptor beta; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine; Belongs to the nuclear hormone receptor family. NR1 subfamily. (476 aa)
NPYC-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (645 aa)
TIPARPTCDD inducible poly(ADP-ribose) polymerase. (670 aa)
TRHDEThyrotropin releasing hormone degrading enzyme. (1037 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems; Belongs to the TRH family. (260 aa)
GHRLPreproghrelin. (116 aa)
SSTSomatostatin-14; Somatostatin inhibits the release of somatotropin. (116 aa)
APODApolipoprotein D; Belongs to the calycin superfamily. Lipocalin family. (189 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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