STRINGSTRING
RABIF RABIF STAT6 STAT6 CD8A-3 CD8A-3 SH2D6 SH2D6 IFNA3 IFNA3 TRAF2 TRAF2 IL6 IL6 CDC42 CDC42 PLEK PLEK CD4 CD4 AKT2 AKT2 ACTB ACTB CD8A-2 CD8A-2 STUB1 STUB1 FOXO1 FOXO1 PTPRZ1 PTPRZ1 LGALS3 LGALS3 EGR3 EGR3 COL3A1 COL3A1 STAT1 STAT1 BTK BTK EGR2 EGR2 VAV2 VAV2 GAS6 GAS6 FOXP1 FOXP1 MYD88 MYD88 CD40 CD40 RAC2 RAC2 SYK SYK IRF4 IRF4 PLEK2 PLEK2 AXL AXL TLR4 TLR4 CBL CBL BCR BCR CD40LG CD40LG CRKL CRKL CARD11 CARD11 NEDD4 NEDD4 SRC SRC PTEN PTEN STAT3 STAT3 ZAP70 ZAP70 LCK LCK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RABIFRAB interacting factor. (209 aa)
STAT6SH2 domain-containing protein. (183 aa)
CD8A-3Ig-like domain-containing protein. (318 aa)
SH2D6B-cell linker protein; Functions as a central linker protein, downstream of the B- cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR- mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-medi [...] (598 aa)
IFNA3Interferon. (193 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (544 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] (194 aa)
PLEKUncharacterized protein. (353 aa)
CD4Uncharacterized protein. (487 aa)
AKT2Non-specific serine/threonine protein kinase. (881 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
CD8A-2Ig-like domain-containing protein. (235 aa)
STUB1STIP1 homology and U box-containing protein 1; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Mediates polyubiquitination of DNA polymerase beta (POLB), thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. May ubiquitinate EPHA2 and regulate the receptor stability and activity through proteasomal degradation. (314 aa)
FOXO1Fork-head domain-containing protein. (727 aa)
PTPRZ1Protein-tyrosine-phosphatase. (2343 aa)
LGALS3Galectin. (258 aa)
EGR3Early growth response 3. (396 aa)
COL3A1Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa)
STAT1Signal transducer and activator of transcription. (755 aa)
BTKTyrosine-protein kinase BTK; Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker prote [...] (684 aa)
EGR2Zinc-finger transcription factor KROX20. (462 aa)
VAV2Uncharacterized protein. (844 aa)
GAS6Growth arrest specific 6. (667 aa)
FOXP1Forkhead box protein P1; Transcriptional repressor. (686 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (299 aa)
CD40Uncharacterized protein. (299 aa)
RAC2Uncharacterized protein. (192 aa)
SYKTyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can a [...] (636 aa)
IRF4Interferon regulatory factor 4. (445 aa)
PLEK2Uncharacterized protein. (355 aa)
AXLTyrosine-protein kinase receptor TYRO3; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, enhances PI3- kinase activity and activates the AKT survival pathway, including nuclear translocation of NF-kappa-B [...] (873 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
CBLUncharacterized protein. (903 aa)
BCRBCR activator of RhoGEF and GTPase. (1351 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Belongs to the tumor necrosis factor family. (272 aa)
CRKLCRK like proto-oncogene, adaptor protein. (193 aa)
CARD11Uncharacterized protein. (1170 aa)
NEDD4E3 ubiquitin-protein ligase. (932 aa)
SRCProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (539 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (423 aa)
STAT3Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa)
ZAP70Tyrosine-protein kinase. (609 aa)
LCKProto-oncogene tyrosine-protein kinase LCK; Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways (By similarity); Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. (508 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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