STRINGSTRING
TLR3 TLR3 CCL20 CCL20 MX1 MX1 RSAD2 RSAD2 IRF7 IRF7 EGF EGF IFIH1 IFIH1 IRF2 IRF2 CD8A-2 CD8A-2 IL6 IL6 ISG20 ISG20 IFNA3 IFNA3 TLR7 TLR7 IRF1 IRF1 CD8A-3 CD8A-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
CCL20C-C motif chemokine. (100 aa)
MX1Interferon-induced GTP-binding protein Mx; Does not show activity against influenza virus, VSV, Thogoto virus or Sendai virus. (705 aa)
RSAD2Viperin. (354 aa)
IRF7Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...] (491 aa)
EGFUncharacterized protein. (1283 aa)
IFIH1Uncharacterized protein. (1102 aa)
IRF2Interferon regulatory factor 2; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation (By similarity). (414 aa)
CD8A-2Ig-like domain-containing protein. (235 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
ISG20Interferon stimulated exonuclease gene 20. (258 aa)
IFNA3Interferon. (193 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1059 aa)
IRF1Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family. (414 aa)
CD8A-3Ig-like domain-containing protein. (318 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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