(36 nodes) (2019) Innate Immune Responses to Avian Influenza Viruses in Ducks and Chickens. network (Gallus gallus)

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Known Interactions

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Predicted Interactions

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Your Input:
	TICAM1	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (735 aa)
	IRF7	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...] (491 aa)
	RSAD2	Viperin. (354 aa)
	MX1	Interferon-induced GTP-binding protein Mx; Does not show activity against influenza virus, VSV, Thogoto virus or Sendai virus. (705 aa)
	CGAS	Cyclic GMP-AMP synthase. (294 aa)
	IFI6	Putative ISG12(2) protein. (107 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
	LSM14A	mRNA processing body assembly factor. (461 aa)
	CD8A-3	Ig-like domain-containing protein. (318 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1059 aa)
	IFNA3	Interferon. (193 aa)
	CASP1	Uncharacterized protein; Belongs to the peptidase C14A family. (540 aa)
	CCL19	C-C motif chemokine. (108 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
	CD4	Uncharacterized protein. (487 aa)
	IFIT5	Uncharacterized protein. (479 aa)
	CD8A-2	Ig-like domain-containing protein. (235 aa)
	TRIM25	Tripartite motif containing 25. (633 aa)
	LAMP1	Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; Belongs to the LAMP family. (406 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
	DHX58	Uncharacterized protein. (674 aa)
	IFITM5	Uncharacterized protein. (131 aa)
	LOC422993	Interferon-inducible transmembrane protein 1. (113 aa)
	IL18	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. (198 aa)
	FURIN	Trans Golgi network protease furin; Belongs to the peptidase S8 family. (789 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (164 aa)
	EIF2AK2	Uncharacterized protein. (550 aa)
	MAVS	CARD_2 domain-containing protein. (641 aa)
	RNASEL	Uncharacterized protein. (686 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	CCR7	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	TRIM27.1	Tripartite motif protein 27. (495 aa)
	IFIH1	Uncharacterized protein. (1102 aa)
	TRIM7.2	Tripartite motif protein 7. (505 aa)
	CCL19-2	SCY domain-containing protein. (99 aa)
	LOC770612	Uncharacterized protein. (137 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP1	CD4	ENSGALP00000070056	ENSGALP00000065611	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.636
CASP1	CD8A-2	ENSGALP00000070056	ENSGALP00000059832	Uncharacterized protein; Belongs to the peptidase C14A family.	Ig-like domain-containing protein.	0.635
CASP1	CD8A-3	ENSGALP00000070056	ENSGALP00000071819	Uncharacterized protein; Belongs to the peptidase C14A family.	Ig-like domain-containing protein.	0.634
CASP1	CGAS	ENSGALP00000070056	ENSGALP00000025623	Uncharacterized protein; Belongs to the peptidase C14A family.	Cyclic GMP-AMP synthase.	0.594
CASP1	DHX58	ENSGALP00000070056	ENSGALP00000005315	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.414
CASP1	EIF2AK2	ENSGALP00000070056	ENSGALP00000017163	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.551
CASP1	IFIH1	ENSGALP00000070056	ENSGALP00000047949	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.561
CASP1	IFNA3	ENSGALP00000070056	ENSGALP00000070204	Uncharacterized protein; Belongs to the peptidase C14A family.	Interferon.	0.703
CASP1	IFNG	ENSGALP00000070056	ENSGALP00000016086	Uncharacterized protein; Belongs to the peptidase C14A family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.609
CASP1	IL10	ENSGALP00000070056	ENSGALP00000001310	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.723
CASP1	IL18	ENSGALP00000070056	ENSGALP00000012772	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	0.998
CASP1	IL1B	ENSGALP00000070056	ENSGALP00000050171	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-1; Belongs to the IL-1 family.	0.998
CASP1	IL6	ENSGALP00000070056	ENSGALP00000068117	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.856
CASP1	IRF7	ENSGALP00000070056	ENSGALP00000038233	Uncharacterized protein; Belongs to the peptidase C14A family.	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...]	0.730
CASP1	MAVS	ENSGALP00000070056	ENSGALP00000051532	Uncharacterized protein; Belongs to the peptidase C14A family.	CARD_2 domain-containing protein.	0.602
CASP1	MX1	ENSGALP00000070056	ENSGALP00000025952	Uncharacterized protein; Belongs to the peptidase C14A family.	Interferon-induced GTP-binding protein Mx; Does not show activity against influenza virus, VSV, Thogoto virus or Sendai virus.	0.515
CASP1	RNASEL	ENSGALP00000070056	ENSGALP00000050610	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.524
CASP1	TLR3	ENSGALP00000070056	ENSGALP00000021914	Uncharacterized protein; Belongs to the peptidase C14A family.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.750
CASP1	TLR7	ENSGALP00000070056	ENSGALP00000070844	Uncharacterized protein; Belongs to the peptidase C14A family.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.654
CCL19	CCL19-2	ENSGALP00000068348	ENSGALP00000043299	C-C motif chemokine.	SCY domain-containing protein.	0.841