(11 nodes) (2019) Immunes-boosting agent: Immunomodulation potentials of propolis. network (Gallus gallus)

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Known Interactions

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Predicted Interactions

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Your Input:
	TLR2A	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (955 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	IL4	Interleukin 4. (136 aa)
	OVAL	Ovalbumin; Non-inhibitory serpin. Storage protein of egg white. (386 aa)
	CD8A-3	Ig-like domain-containing protein. (318 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (283 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (164 aa)
	CD4	Uncharacterized protein. (487 aa)
	CD8A-2	Ig-like domain-containing protein. (235 aa)
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	CD4	ENSGALP00000068843	ENSGALP00000065611	Caspase-3; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.732
CASP3	CD8A-2	ENSGALP00000068843	ENSGALP00000059832	Caspase-3; Belongs to the peptidase C14A family.	Ig-like domain-containing protein.	0.708
CASP3	CD8A-3	ENSGALP00000068843	ENSGALP00000071819	Caspase-3; Belongs to the peptidase C14A family.	Ig-like domain-containing protein.	0.708
CASP3	IFNG	ENSGALP00000068843	ENSGALP00000016086	Caspase-3; Belongs to the peptidase C14A family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.678
CASP3	IL1B	ENSGALP00000068843	ENSGALP00000050171	Caspase-3; Belongs to the peptidase C14A family.	Interleukin-1; Belongs to the IL-1 family.	0.887
CASP3	IL4	ENSGALP00000068843	ENSGALP00000039130	Caspase-3; Belongs to the peptidase C14A family.	Interleukin 4.	0.584
CASP3	IL6	ENSGALP00000068843	ENSGALP00000068117	Caspase-3; Belongs to the peptidase C14A family.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.911
CASP3	OVAL	ENSGALP00000068843	ENSGALP00000036403	Caspase-3; Belongs to the peptidase C14A family.	Ovalbumin; Non-inhibitory serpin. Storage protein of egg white.	0.526
CASP3	TLR2A	ENSGALP00000068843	ENSGALP00000050968	Caspase-3; Belongs to the peptidase C14A family.	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).	0.487
CASP3	TLR4	ENSGALP00000068843	ENSGALP00000011319	Caspase-3; Belongs to the peptidase C14A family.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.749
CD4	CASP3	ENSGALP00000065611	ENSGALP00000068843	Uncharacterized protein.	Caspase-3; Belongs to the peptidase C14A family.	0.732
CD4	CD8A-2	ENSGALP00000065611	ENSGALP00000059832	Uncharacterized protein.	Ig-like domain-containing protein.	0.984
CD4	CD8A-3	ENSGALP00000065611	ENSGALP00000071819	Uncharacterized protein.	Ig-like domain-containing protein.	0.982
CD4	IFNG	ENSGALP00000065611	ENSGALP00000016086	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.989
CD4	IL1B	ENSGALP00000065611	ENSGALP00000050171	Uncharacterized protein.	Interleukin-1; Belongs to the IL-1 family.	0.957
CD4	IL4	ENSGALP00000065611	ENSGALP00000039130	Uncharacterized protein.	Interleukin 4.	0.979
CD4	IL6	ENSGALP00000065611	ENSGALP00000068117	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.982
CD4	OVAL	ENSGALP00000065611	ENSGALP00000036403	Uncharacterized protein.	Ovalbumin; Non-inhibitory serpin. Storage protein of egg white.	0.979
CD4	TLR2A	ENSGALP00000065611	ENSGALP00000050968	Uncharacterized protein.	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).	0.856
CD4	TLR4	ENSGALP00000065611	ENSGALP00000011319	Uncharacterized protein.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.888