(23 nodes) (2019) Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells. network (Gallus gallus)

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Known Interactions

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Predicted Interactions

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protein homology

Your Input:
	CD34	CD34 molecule. (385 aa)
	PODXL	Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro- adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubul [...] (589 aa)
	GATA3	GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (283 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
	ENG	ZP domain-containing protein. (714 aa)
	WNT4	Protein Wnt-4; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development (By similarity). (351 aa)
	HOXD11	Homeobox protein Hox-D11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (280 aa)
	PAX2	Paired-box containing protein Pax-2. (394 aa)
	ALB	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. (565 aa)
	FOXP1	Forkhead box protein P1; Transcriptional repressor. (686 aa)
	SALL1	Uncharacterized protein. (1308 aa)
	SIX2	Sine oculis-related homeobox 2 homolog. (287 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	BMP4	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. (404 aa)
	WT1	Uncharacterized protein. (417 aa)
	SLC3A1	Solute carrier family 3 member 1. (678 aa)
	RPLP0	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10; Belongs to the universal ribosomal protein uL10 family. (350 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
	SCNN1B	Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (667 aa)
	LHX1	LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2. (406 aa)
	NPHS2	NPHS2 stomatin family member, podocin. (384 aa)
	VTN	SMB domain-containing protein. (453 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	BMP4	ENSGALP00000044604	ENSGALP00000020289	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	0.615
ALB	CASP3	ENSGALP00000044604	ENSGALP00000068843	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Caspase-3; Belongs to the peptidase C14A family.	0.857
ALB	CD34	ENSGALP00000044604	ENSGALP00000001784	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	CD34 molecule.	0.725
ALB	FGF9	ENSGALP00000044604	ENSGALP00000041598	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.626
ALB	FOXP1	ENSGALP00000044604	ENSGALP00000044290	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Forkhead box protein P1; Transcriptional repressor.	0.601
ALB	GAPDH	ENSGALP00000044604	ENSGALP00000063325	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	0.954
ALB	INS	ENSGALP00000044604	ENSGALP00000010567	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.975
ALB	NPHS2	ENSGALP00000044604	ENSGALP00000006610	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	NPHS2 stomatin family member, podocin.	0.521
ALB	VTN	ENSGALP00000044604	ENSGALP00000005668	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	SMB domain-containing protein.	0.793
ALB	WT1	ENSGALP00000044604	ENSGALP00000019761	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Uncharacterized protein.	0.403
BMP4	ALB	ENSGALP00000020289	ENSGALP00000044604	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	0.615
BMP4	CASP3	ENSGALP00000020289	ENSGALP00000068843	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	Caspase-3; Belongs to the peptidase C14A family.	0.526
BMP4	CD34	ENSGALP00000020289	ENSGALP00000001784	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	CD34 molecule.	0.620
BMP4	FGF9	ENSGALP00000020289	ENSGALP00000041598	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.865
BMP4	GAPDH	ENSGALP00000020289	ENSGALP00000063325	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	0.682
BMP4	GATA3	ENSGALP00000020289	ENSGALP00000068882	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.	0.603
BMP4	INS	ENSGALP00000020289	ENSGALP00000010567	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.768
BMP4	LHX1	ENSGALP00000020289	ENSGALP00000008672	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2.	0.491
BMP4	PAX2	ENSGALP00000020289	ENSGALP00000045193	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	Paired-box containing protein Pax-2.	0.708
BMP4	SIX2	ENSGALP00000020289	ENSGALP00000043451	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	Sine oculis-related homeobox 2 homolog.	0.545