STRINGSTRING
NR0B1 NR0B1 TAB3 TAB3 KHDRBS2 KHDRBS2 USP9Y USP9Y DDX3X DDX3X KDM6A KDM6A U2AF1 U2AF1 MSX1 MSX1 DDX4 DDX4 MXD1 MXD1 JARID2 JARID2 SOX10 SOX10 AMHR2 AMHR2 PHF5A PHF5A SNW1 SNW1 SRSF5 SRSF5 FMR1 FMR1 SMNDC1 SMNDC1 MXI1 MXI1 AMOT AMOT SF3A1 SF3A1 COX7B COX7B PCGF5 PCGF5 SOX6 SOX6 SOX8 SOX8 BCORL1 BCORL1 SETX SETX RBBP4 RBBP4 LSM4 LSM4 PRPF8 PRPF8 RSPO1 RSPO1 MED1 MED1 PPP1R8 PPP1R8 SOX13 SOX13 BIRC8 BIRC8 ZRSR2 ZRSR2 GATA4 GATA4 CYP17A1 CYP17A1 KDM3A KDM3A CBX2 CBX2 EIF4A3 EIF4A3 RPL39L RPL39L ALPL ALPL SF3B6 SF3B6 GADD45G GADD45G FGF9 FGF9 SNRNP25 SNRNP25 SOX5 SOX5 ENSGALP00000044025 ENSGALP00000044025 CHTF18 CHTF18 MSL2 MSL2 FGFR2 FGFR2 CTNNB1 CTNNB1 FOXL2 FOXL2 WNT4 WNT4 SHROOM4 SHROOM4 IRX3 IRX3 SF3B5 SF3B5 XPO1 XPO1 SOX4 SOX4 LSM3 LSM3 CYP11A1 CYP11A1 AMH AMH SCMH1 SCMH1 RSRC1 RSRC1 TGFBR1 TGFBR1 TSPAN33 TSPAN33 RBM10 RBM10 LEFTY1 LEFTY1 ENO1 ENO1 CWC15 CWC15 KPNA2 KPNA2 SON SON FLNA FLNA CLCN5 CLCN5 MBNL3 MBNL3 HDAC7 HDAC7 POLA1 POLA1 DOCK9 DOCK9 ARID5A ARID5A HSD3B1 HSD3B1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NR0B1NR LBD domain-containing protein. (263 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (679 aa)
KHDRBS2KH RNA binding domain containing, signal transduction associated 2. (348 aa)
USP9YUSP domain-containing protein; Belongs to the peptidase C19 family. (2552 aa)
DDX3XDEAD-box helicase 3,X-linked; Belongs to the DEAD box helicase family. (651 aa)
KDM6AUncharacterized protein. (1484 aa)
U2AF1U2snRNP auxiliary factor small subunit. (237 aa)
MSX1Homeobox protein GHOX-7; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death. (288 aa)
DDX4Uncharacterized protein; Belongs to the DEAD box helicase family. (663 aa)
MXD1BHLH domain-containing protein. (206 aa)
JARID2Protein Jumonji; Regulator of histone methyltransferase complexes that plays an essential role in embryonic development. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone [...] (1235 aa)
SOX10Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. (461 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (678 aa)
PHF5AUncharacterized protein. (110 aa)
SNW1SNW domain containing 1. (538 aa)
SRSF5Uncharacterized protein. (264 aa)
FMR1Fragile X mental retardation 1. (548 aa)
SMNDC1Survival motor neuron domain containing 1. (238 aa)
MXI1BHLH domain-containing protein. (264 aa)
AMOTAngiomotin. (910 aa)
SF3A1Uncharacterized protein. (790 aa)
COX7BUncharacterized protein. (79 aa)
PCGF5RING-type domain-containing protein. (256 aa)
SOX6HMG box domain-containing protein. (817 aa)
SOX8Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. (470 aa)
BCORL1BCL6 corepressor like 1. (1651 aa)
SETXSenataxin. (2801 aa)
RBBP4Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. (425 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (138 aa)
PRPF8Pre-mRNA processing factor 8. (2335 aa)
RSPO1R-spondin 1. (260 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
PPP1R8FHA domain-containing protein. (354 aa)
SOX13SRY-box transcription factor 13. (666 aa)
BIRC8Inhibitor of apoptosis protein 3. (493 aa)
ZRSR2Zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2. (333 aa)
GATA4Transcription factor GATA-4; Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). (410 aa)
CYP17A1Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. (527 aa)
KDM3ALysine-specific demethylase 3A; Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate (By similarity). (1325 aa)
CBX2Chromobox 2. (528 aa)
EIF4A3Eukaryotic initiation factor 4A-III; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the [...] (412 aa)
RPL39L60S ribosomal protein L39. (51 aa)
ALPLAlkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. (519 aa)
SF3B6Splicing factor 3b subunit 6. (91 aa)
GADD45GGrowth arrest and DNA-damage-inducible protein 45 gamma. (159 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
SNRNP25Small nuclear ribonucleoprotein U11/U12 subunit 25. (129 aa)
SOX5Transcription factor LSox5-II. (772 aa)
ENSGALP00000044025Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (617 aa)
CHTF18AAA domain-containing protein. (951 aa)
MSL2MSL complex subunit 2. (579 aa)
FGFR2Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] (824 aa)
CTNNB1Uncharacterized protein. (781 aa)
FOXL2Transcription factor FOXL2. (305 aa)
WNT4Protein Wnt-4; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development (By similarity). (351 aa)
SHROOM4Shroom family member 4. (1224 aa)
IRX3Iroquois homeobox 3. (445 aa)
SF3B5Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa)
XPO1Importin N-terminal domain-containing protein. (1071 aa)
SOX4Transcription factor SOX. (428 aa)
LSM3Uncharacterized protein. (102 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (508 aa)
AMHTGF_BETA_2 domain-containing protein. (644 aa)
SCMH1Scm polycomb group protein homolog 1. (703 aa)
RSRC1Arginine and serine rich coiled-coil 1. (306 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
TSPAN33Tetraspanin. (324 aa)
RBM10Uncharacterized protein. (911 aa)
LEFTY1Left-right determination factor. (362 aa)
ENO1Alpha-enolase. (447 aa)
CWC15Uncharacterized protein. (230 aa)
KPNA2Importin subunit alpha; Belongs to the importin alpha family. (528 aa)
SONUncharacterized protein. (2900 aa)
FLNAUncharacterized protein. (492 aa)
CLCN5Chloride channel protein. (826 aa)
MBNL3Uncharacterized protein. (371 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1250 aa)
POLA1DNA polymerase. (1496 aa)
DOCK9Dedicator of cytokinesis 9; Belongs to the DOCK family. (2105 aa)
ARID5AAT-rich interaction domain 5A. (618 aa)
HSD3B13Beta_HSD domain-containing protein. (484 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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