STRINGSTRING
CD82 CD82 RAB14 RAB14 TRADD TRADD UPF1 UPF1 ACTR5 ACTR5 SRC SRC SERPINE2 SERPINE2 CD81 CD81 HBZ HBZ FGF4 FGF4 FGF16 FGF16 CAV3 CAV3 TBK1 TBK1 ADSS ADSS METAP2 METAP2 ACTR3 ACTR3 CTSV CTSV RDX RDX TLR3 TLR3 FGF20 FGF20 KDR KDR EIF2S3 EIF2S3 IL17A IL17A FGF14 FGF14 FGF6 FGF6 CD9 CD9 CAMP CAMP MCM6 MCM6 FGF8 FGF8 NME2 NME2 MYL2 MYL2 PSMC3 PSMC3 EIF4A3 EIF4A3 CD40 CD40 B2M B2M FGF9 FGF9 S100A10 S100A10 FGF23 FGF23 CATH1 CATH1 FGF3 FGF3 FGF7 FGF7 FGF19 FGF19 EGF EGF MSN MSN FGF22 FGF22 PRDX1 PRDX1 LDHB LDHB HGF HGF IL1B IL1B DCTN2 DCTN2 FGF12 FGF12 MEF2C MEF2C HBAD HBAD EGFR EGFR FGF13 FGF13 BCL2L1 BCL2L1 FGF18 FGF18 KRAS KRAS CD44 CD44 CD8A-2 CD8A-2 ACTB ACTB GAPDH GAPDH CAV2 CAV2 FGF10 FGF10 FGF5 FGF5 CD4 CD4 TRAF3 TRAF3 IL6 IL6 PDCD4 PDCD4 NFATC1 NFATC1 ATP6V1A ATP6V1A PTK2 PTK2 RAB2A RAB2A CD8A-3 CD8A-3 FGF11 FGF11 CD63 CD63
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD82Tetraspanin. (264 aa)
RAB14Ras-related protein Rab-14; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development (By similarity); Belongs to the small GTPase superfamily. Rab family. (215 aa)
TRADDTNFRSF1A associated via death domain. (461 aa)
UPF1UPF1 RNA helicase and ATPase. (1117 aa)
ACTR5Actin-related protein 5; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. (611 aa)
SRCProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (539 aa)
SERPINE2SERPIN domain-containing protein; Belongs to the serpin family. (442 aa)
CD81Tetraspanin. (237 aa)
HBZHemoglobin subunit pi; The pi' chain is the counterpart of the alpha chain in the major early embryonic hemoglobin P; Belongs to the globin family. (142 aa)
FGF4Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb development during embryogenesis (By similarity). (194 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
TBK1Protein kinase domain-containing protein. (729 aa)
ADSSAdenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (516 aa)
METAP2Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. (479 aa)
ACTR3Actin-related protein 3; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged [...] (418 aa)
CTSVCathepsin L1 heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. (353 aa)
RDXRadixin; Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. (583 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1348 aa)
EIF2S3Eukaryotic translation initiation factor 2 subunit 3; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...] (472 aa)
IL17AUncharacterized protein. (169 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (253 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
CD9Tetraspanin. (224 aa)
CAMPCathelicidin-2; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response. (154 aa)
MCM6DNA helicase; Belongs to the MCM family. (825 aa)
FGF8Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
NME2Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). (153 aa)
MYL2Myosin regulatory light chain 2A, cardiac muscle isoform. (202 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (422 aa)
EIF4A3Eukaryotic initiation factor 4A-III; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the [...] (412 aa)
CD40Uncharacterized protein. (299 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
S100A10Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. (97 aa)
FGF23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (254 aa)
CATH1Cathelicidin-1; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response. (148 aa)
FGF3Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (220 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
EGFUncharacterized protein. (1283 aa)
MSNMoesin. (580 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (176 aa)
PRDX1Peroxiredoxin-1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron diffe [...] (199 aa)
LDHBL-lactate dehydrogenase B chain; Belongs to the LDH/MDH superfamily. LDH family. (333 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (726 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
DCTN2Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). (408 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
HBADHemoglobin subunit alpha-D; Involved in oxygen transport from the lung to the various peripheral tissues. (141 aa)
EGFREpidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...] (1226 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
BCL2L1Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity). (229 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
KRASUncharacterized protein. (189 aa)
CD44Link domain-containing protein. (696 aa)
CD8A-2Ig-like domain-containing protein. (235 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (161 aa)
FGF10Uncharacterized protein. (261 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (292 aa)
CD4Uncharacterized protein. (487 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
PDCD4Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds RNA (By similarity). Does not seem to be involved in apoptosis. (467 aa)
NFATC1Nuclear factor of activated T cells 1. (909 aa)
ATP6V1AV-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity. Belongs to the ATPase alpha/beta chains family. (617 aa)
PTK2Focal adhesion kinase 1; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous s [...] (1102 aa)
RAB2ARas-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex; Belongs to the small GTPase superfamily. Rab family. (212 aa)
CD8A-3Ig-like domain-containing protein. (318 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
CD63Tetraspanin. (227 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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