STRINGSTRING
MMP2 MMP2 TIMP2 TIMP2 STAT1 STAT1 IL7 IL7 STAT2 STAT2 RECK RECK CD8A-2 CD8A-2 CD38 CD38 PDCD1 PDCD1 CASP18 CASP18 IL6 IL6 CASP3 CASP3 IL15 IL15 IFNA3 IFNA3 CD8A-3 CD8A-3 IL4 IL4 CASP8 CASP8 CTLA4 CTLA4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MMP272 kDa type IV collagenase; Belongs to the peptidase M10A family. (663 aa)
TIMP2Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. (220 aa)
STAT1Signal transducer and activator of transcription. (755 aa)
IL7Interleukin-7. (146 aa)
STAT2Signal transducer and activator of transcription. (961 aa)
RECKReversion-inducing cysteine-rich protein with Kazal motifs; Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (By similarity). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7. ADGRA2 is then required to del [...] (963 aa)
CD8A-2Ig-like domain-containing protein. (235 aa)
CD38Uncharacterized protein. (308 aa)
PDCD1Ig-like domain-containing protein. (304 aa)
CASP18Initiator caspase; Belongs to the peptidase C14A family. (464 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (283 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (187 aa)
IFNA3Interferon. (193 aa)
CD8A-3Ig-like domain-containing protein. (318 aa)
IL4Interleukin 4. (136 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
CTLA4Cytotoxic T-lymphocyte-associated protein 4. (205 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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