31 items (Gallus gallus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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	SST	Somatostatin-14; Somatostatin inhibits the release of somatotropin. (116 aa)
	FAM107A	Family with sequence similarity 107 member A. (175 aa)
	DLX1	Homeodomain transcription factor DLX1. (255 aa)
	GDNF	Glial cell derived neurotrophic factor. (209 aa)
	MAP2	Microtubule-associated protein. (1955 aa)
	AQP4	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (417 aa)
	TBR1	T-box brain transcription factor 1. (677 aa)
	LHX6	LIM homeobox 6. (380 aa)
	SATB2	DNA-binding protein SATB. (731 aa)
	CALB2	Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons. (311 aa)
	OVAL	Ovalbumin; Non-inhibitory serpin. Storage protein of egg white. (386 aa)
	HBBA	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. The beta chain is a component of adult hemoglobin A and D. (147 aa)
	HBE1	Beta-H globin; Belongs to the globin family. (147 aa)
	NIN	Ninein. (2081 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators (By similarity). (811 aa)
	FOXP2	Fork-head domain-containing protein. (513 aa)
	RELN	Reelin; Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity); Belongs to the reel [...] (3462 aa)
	HBZ	Hemoglobin subunit pi; The pi' chain is the counterpart of the alpha chain in the major early embryonic hemoglobin P; Belongs to the globin family. (142 aa)
	NEUROD2	Neurogenic differentiation factor. (356 aa)
	HBA1	Hemoglobin subunit alpha-A; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (142 aa)
	ANGPT1	Fibrinogen C-terminal domain-containing protein. (498 aa)
	RSPO2	R-spondin 2. (241 aa)
	RBFOX3	RNA binding fox-1 homolog 3. (486 aa)
	GAD1	Glutamate decarboxylase 67. (590 aa)
	NKX2-1	Homeobox domain-containing protein. (345 aa)
	ANGPT2	Angiopoietin-2A. (493 aa)
	MKI67	FHA domain-containing protein. (2570 aa)
	MBP	Myelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). (308 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (283 aa)
	PAX6	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development. (500 aa)
	BDNF	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (254 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGPT1	HIF1A	ENSGALP00000050106	ENSGALP00000019338	Fibrinogen C-terminal domain-containing protein.	Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators (By similarity).	0.692
ANGPT2	HIF1A	ENSGALP00000064997	ENSGALP00000019338	Angiopoietin-2A.	Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators (By similarity).	0.636
AQP4	BDNF	ENSGALP00000073366	ENSGALP00000071950	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	0.454
AQP4	CASP3	ENSGALP00000073366	ENSGALP00000068843	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Caspase-3; Belongs to the peptidase C14A family.	0.439
AQP4	GAD1	ENSGALP00000073366	ENSGALP00000053512	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Glutamate decarboxylase 67.	0.456
AQP4	MBP	ENSGALP00000073366	ENSGALP00000065604	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Myelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).	0.691
AQP4	RBFOX3	ENSGALP00000073366	ENSGALP00000053277	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	RNA binding fox-1 homolog 3.	0.486
BDNF	AQP4	ENSGALP00000071950	ENSGALP00000073366	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.454
BDNF	CALB2	ENSGALP00000071950	ENSGALP00000041715	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons.	0.541
BDNF	CASP3	ENSGALP00000071950	ENSGALP00000068843	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Caspase-3; Belongs to the peptidase C14A family.	0.740
BDNF	GAD1	ENSGALP00000071950	ENSGALP00000053512	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Glutamate decarboxylase 67.	0.709
BDNF	GDNF	ENSGALP00000071950	ENSGALP00000005887	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Glial cell derived neurotrophic factor.	0.985
BDNF	MAP2	ENSGALP00000071950	ENSGALP00000072455	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Microtubule-associated protein.	0.773
BDNF	MBP	ENSGALP00000071950	ENSGALP00000065604	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Myelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).	0.694
BDNF	NEUROD2	ENSGALP00000071950	ENSGALP00000049753	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Neurogenic differentiation factor.	0.416
BDNF	PAX6	ENSGALP00000071950	ENSGALP00000070449	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development.	0.682
BDNF	RBFOX3	ENSGALP00000071950	ENSGALP00000053277	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	RNA binding fox-1 homolog 3.	0.420
BDNF	SST	ENSGALP00000071950	ENSGALP00000011889	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Somatostatin-14; Somatostatin inhibits the release of somatotropin.	0.562
BDNF	TBR1	ENSGALP00000071950	ENSGALP00000048357	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	T-box brain transcription factor 1.	0.506
CALB2	BDNF	ENSGALP00000041715	ENSGALP00000071950	Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons.	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	0.541