(26 nodes) (2020) A quantitative trait locus on chromosome 2 was identified that accounts for a substantial proportion of phenotypic variance of the yellow plumage color in chicken. network (Gallus gallus)

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Your Input:
	CHST11	Carbohydrate sulfotransferase. (342 aa)
	THOC1	Death domain-containing protein. (671 aa)
	SLC52A3	Solute carrier family 52 member 3. (454 aa)
	TMEM241	Transmembrane protein 241. (340 aa)
	CDH22	Cadherin 22; Cadherins are calcium-dependent cell adhesion proteins. (802 aa)
	CDK6	Cyclin-dependent kinase; Belongs to the protein kinase superfamily. (326 aa)
	SLC24A4	Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (528 aa)
	SLC38A6	Solute carrier family 38 member 6. (466 aa)
	SLC41A2	Solute carrier family 41 member 2; Acts as a plasma-membrane magnesium transporter. Belongs to the SLC41A transporter family. (573 aa)
	BCL2	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
	GREB1L	GREB1 like retinoic acid receptor coactivator. (1930 aa)
	CABLES1	Cdk5 and Abl enzyme substrate 1. (309 aa)
	TYR	Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. (537 aa)
	GATA6	Transcription factor GATA-6; Transcriptional activator. (387 aa)
	TYRP1	5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. (536 aa)
	SLC24A5	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (423 aa)
	SLC35C2	TPT domain-containing protein. (358 aa)
	LAMA3	Laminin subunit alpha 3. (3448 aa)
	SLC12A5	Solute carrier family 12 member 5. (1130 aa)
	ANKRD29	Ankyrin repeat domain 29. (305 aa)
	ZNF521	Zinc finger protein 521. (1419 aa)
	YES1	Tyrosine-protein kinase Yes; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, differentiation, G2/M progression and cytokinesis. (541 aa)
	KIT	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...] (960 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
	BCL2L1	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity). (229 aa)
	EDN3	Endothelin 3. (151 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD29	CABLES1	ENSGALP00000045540	ENSGALP00000024140	Ankyrin repeat domain 29.	Cdk5 and Abl enzyme substrate 1.	0.725
ANKRD29	CDH22	ENSGALP00000045540	ENSGALP00000011656	Ankyrin repeat domain 29.	Cadherin 22; Cadherins are calcium-dependent cell adhesion proteins.	0.730
ANKRD29	CHST11	ENSGALP00000045540	ENSGALP00000054531	Ankyrin repeat domain 29.	Carbohydrate sulfotransferase.	0.629
ANKRD29	GREB1L	ENSGALP00000045540	ENSGALP00000024043	Ankyrin repeat domain 29.	GREB1 like retinoic acid receptor coactivator.	0.744
ANKRD29	LAMA3	ENSGALP00000045540	ENSGALP00000043775	Ankyrin repeat domain 29.	Laminin subunit alpha 3.	0.712
ANKRD29	SLC35C2	ENSGALP00000045540	ENSGALP00000038307	Ankyrin repeat domain 29.	TPT domain-containing protein.	0.600
ANKRD29	THOC1	ENSGALP00000045540	ENSGALP00000060209	Ankyrin repeat domain 29.	Death domain-containing protein.	0.716
ANKRD29	TMEM241	ENSGALP00000045540	ENSGALP00000074312	Ankyrin repeat domain 29.	Transmembrane protein 241.	0.874
ANKRD29	ZNF521	ENSGALP00000045540	ENSGALP00000048766	Ankyrin repeat domain 29.	Zinc finger protein 521.	0.729
BCL2	BCL2L1	ENSGALP00000020984	ENSGALP00000054103	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).	0.972
BCL2	CDK6	ENSGALP00000020984	ENSGALP00000015412	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Cyclin-dependent kinase; Belongs to the protein kinase superfamily.	0.754
BCL2	KIT	ENSGALP00000020984	ENSGALP00000051217	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...]	0.424
BCL2L1	BCL2	ENSGALP00000054103	ENSGALP00000020984	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.972
BCL2L1	CDK6	ENSGALP00000054103	ENSGALP00000015412	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).	Cyclin-dependent kinase; Belongs to the protein kinase superfamily.	0.559
CABLES1	ANKRD29	ENSGALP00000024140	ENSGALP00000045540	Cdk5 and Abl enzyme substrate 1.	Ankyrin repeat domain 29.	0.725
CABLES1	CDH22	ENSGALP00000024140	ENSGALP00000011656	Cdk5 and Abl enzyme substrate 1.	Cadherin 22; Cadherins are calcium-dependent cell adhesion proteins.	0.488
CABLES1	CDK6	ENSGALP00000024140	ENSGALP00000015412	Cdk5 and Abl enzyme substrate 1.	Cyclin-dependent kinase; Belongs to the protein kinase superfamily.	0.401
CABLES1	CHST11	ENSGALP00000024140	ENSGALP00000054531	Cdk5 and Abl enzyme substrate 1.	Carbohydrate sulfotransferase.	0.428
CABLES1	GREB1L	ENSGALP00000024140	ENSGALP00000024043	Cdk5 and Abl enzyme substrate 1.	GREB1 like retinoic acid receptor coactivator.	0.531
CABLES1	LAMA3	ENSGALP00000024140	ENSGALP00000043775	Cdk5 and Abl enzyme substrate 1.	Laminin subunit alpha 3.	0.417