STRINGSTRING
TBR1 TBR1 ASCL1 ASCL1 SLC18A3 SLC18A3 SOX2 SOX2 ZBTB14 ZBTB14 GAL GAL HIST1H3H HIST1H3H EOMES EOMES ONECUT3 ONECUT3 LANCL3 LANCL3 H3F3C H3F3C SOX10 SOX10 NEUROD1 NEUROD1 SST SST DRAXIN DRAXIN DLX1 DLX1 PRDM12 PRDM12 AGRP AGRP SNCG SNCG PBX3 PBX3 GFAP GFAP CXXC5 CXXC5 NFIA NFIA TH TH RBFOX3 RBFOX3 GAD1 GAD1 TMPRSS9 TMPRSS9 SLC17A6 SLC17A6 TBPL1 TBPL1 ENSGALP00000055994 ENSGALP00000055994 ONECUT2 ONECUT2 ZIC5 ZIC5 MEIS2 MEIS2 TBP TBP POMC POMC NHLH2 NHLH2 DLL1 DLL1 NTRK2 NTRK2 ROBO1 ROBO1 RBPJ RBPJ ENSGALP00000069661 ENSGALP00000069661 ADCYAP1R1 ADCYAP1R1 LHX9 LHX9 SLC1A3 SLC1A3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBR1T-box brain transcription factor 1. (677 aa)
ASCL1BHLH domain-containing protein. (219 aa)
SLC18A3MFS domain-containing protein. (522 aa)
SOX2Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa)
ZBTB14Zinc finger and BTB domain-containing protein 14; Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA- 3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family. (448 aa)
GALGalanin variant 1. (141 aa)
HIST1H3HHistone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
EOMEST-box_assoc domain-containing protein. (661 aa)
ONECUT3One cut domain family member. (468 aa)
LANCL3LanC like 3. (416 aa)
H3F3CHistone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
SOX10Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. (461 aa)
NEUROD1Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa)
SSTSomatostatin-14; Somatostatin inhibits the release of somatotropin. (116 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord and cortical explants in vitro. Binds directly to the neurites and growth cones. (349 aa)
DLX1Homeodomain transcription factor DLX1. (255 aa)
PRDM12PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (351 aa)
AGRPAgouti-related protein. (233 aa)
SNCGGamma-synuclein; Belongs to the synuclein family. (128 aa)
PBX3Homeobox domain-containing protein. (433 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (422 aa)
CXXC5CXXC finger protein 5. (276 aa)
NFIANuclear factor 1 A-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (582 aa)
THTyrosine hydroxylase. (491 aa)
RBFOX3RNA binding fox-1 homolog 3. (486 aa)
GAD1Glutamate decarboxylase 67. (590 aa)
TMPRSS9Transmembrane serine protease 9; Belongs to the peptidase S1 family. (1127 aa)
SLC17A6MFS domain-containing protein. (585 aa)
TBPL1TATA box-binding protein-like protein 1; Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box (By similarity). Belongs to the TBP family. (183 aa)
ENSGALP00000055994Histone H3; Belongs to the histone H3 family. (136 aa)
ONECUT2One cut domain family member. (403 aa)
ZIC5Zic family member 5. (495 aa)
MEIS2Homeoprotein Meis2a.2. (394 aa)
TBPTATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. (302 aa)
POMCUncharacterized protein. (251 aa)
NHLH2BHLH domain-containing protein. (138 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (893 aa)
NTRK2BDNF/NT-3 growth factors receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, [...] (842 aa)
ROBO1Roundabout guidance receptor 1. (1748 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (484 aa)
ENSGALP00000069661Histone H3; Belongs to the histone H3 family. (98 aa)
ADCYAP1R1Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (499 aa)
LHX9LIM/homeobox protein Lhx9; May be involved in gonadal development. (455 aa)
SLC1A3Amino acid transporter. (543 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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