STRINGSTRING
GSTM2 GSTM2 ABCB1 ABCB1 TLR2A TLR2A COL3A1 COL3A1 NR4A1 NR4A1 ABCG2 ABCG2 NPR3 NPR3 ACTB ACTB MGST1 MGST1 CYP19A1 CYP19A1 IL6 IL6 FST FST MYC MYC HRAS HRAS NFE2L2 NFE2L2 ATF3 ATF3 TNFAIP3 TNFAIP3 DHCR24 DHCR24 GPX7 GPX7 HPGDS HPGDS SMARCA2 SMARCA2 MGST2 MGST2 COL1A2 COL1A2 EPHX1 EPHX1 GSTO2 GSTO2 RPLP0 RPLP0 INS INS GSTT1 GSTT1 CYP3A5 CYP3A5 LOC100859347 LOC100859347 DHCR7 DHCR7 MGST3 MGST3 STAT5A STAT5A BRCA1 BRCA1 SIRT1 SIRT1 ADGRD1 ADGRD1 CYP1A2 CYP1A2 BRAF BRAF NR4A3 NR4A3 GSTK1 GSTK1 CYP26B1 CYP26B1 ABCG1 ABCG1 GSTA3 GSTA3 GSTA2 GSTA2 ODC1 ODC1 BIRC3 BIRC3 GJB2 GJB2 SOD1 SOD1 ABCB1-2 ABCB1-2 TLR2B TLR2B FAS FAS CYP1A1 CYP1A1 REL REL GPX1 GPX1 NFKB2 NFKB2 GLCE GLCE GPM6A GPM6A ALB ALB RAF1 RAF1 TNFAIP2 TNFAIP2 EFEMP1 EFEMP1 AHR AHR CYP1B1 CYP1B1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSTM2Glutathione S-transferase 2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family. (220 aa)
ABCB1ATP binding cassette subfamily B member 1. (1293 aa)
TLR2AToll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (955 aa)
COL3A1Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (743 aa)
ABCG2ATP-binding cassette sub-family G member 2. (701 aa)
NPR3Natriuretic peptide receptor 3. (521 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
MGST1Uncharacterized protein. (155 aa)
CYP19A1Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (502 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
FSTFollistatin; Binds directly to activin and functions as an activin antagonist. Inhibits activin A signaling in the iris and regulates somatostatin phenotype in ciliary ganglion neurons. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). (320 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa)
HRASGTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
NFE2L2BZIP domain-containing protein. (593 aa)
ATF3Activating transcription factor 3. (181 aa)
TNFAIP3TNF alpha induced protein 3. (806 aa)
DHCR24FAD-binding PCMH-type domain-containing protein. (516 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (210 aa)
HPGDSHematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide. (199 aa)
SMARCA2Uncharacterized protein. (1594 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
COL1A2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1363 aa)
EPHX1Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. (464 aa)
GSTO2Uncharacterized protein. (239 aa)
RPLP060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10; Belongs to the universal ribosomal protein uL10 family. (350 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
GSTT1Glutathione S-transferase theta-1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Theta family. (261 aa)
CYP3A5Uncharacterized protein. (508 aa)
LOC100859347Uncharacterized protein. (964 aa)
DHCR7Uncharacterized protein. (474 aa)
MGST3Uncharacterized protein. (142 aa)
STAT5ASignal transducer and activator of transcription. (764 aa)
BRCA1Uncharacterized protein. (1749 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (881 aa)
ADGRD1G protein-coupled receptor 133 variant X1; Belongs to the G-protein coupled receptor 2 family. (926 aa)
CYP1A2Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
BRAFSerine/threonine-protein kinase B-raf; Protein kinase involved in the activation of the MAP signaling cascade. May play a role in transducing specific signals in neural cells; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. (806 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (609 aa)
GSTK1Glutathione S-transferase kappa. (224 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa)
ABCG1ATP binding cassette subfamily G member 1. (666 aa)
GSTA3Glutathione S-transferase; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. (221 aa)
GSTA2Glutathione S-transferase; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family. (222 aa)
ODC1Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. (464 aa)
BIRC3Inhibitor of apoptosis protein; Apoptotic suppressor. (610 aa)
GJB2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (225 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (164 aa)
ABCB1-2Multidrug resistance protein 1. (1288 aa)
TLR2BToll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (781 aa)
FASUncharacterized protein. (339 aa)
CYP1A1Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
RELProto-oncogene c-Rel; Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferen [...] (598 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (182 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the indi [...] (913 aa)
GLCEGlucuronic acid epimerase. (573 aa)
GPM6ANeuronal proteolipid GPM6A. (278 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. (565 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions. RAF1 activation initiates a mitogen- activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2) (By similarity). (667 aa)
TNFAIP2TNF alpha induced protein 2. (688 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (451 aa)
AHRUncharacterized protein. (877 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (536 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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