node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHR | CYP1A1 | ENSGALP00000047347 | ENSGALP00000039219 | Uncharacterized protein. | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.458 |
AHR | LOC100859347 | ENSGALP00000047347 | ENSGALP00000006877 | Uncharacterized protein. | Uncharacterized protein. | 0.557 |
APOB | COMT | ENSGALP00000026550 | ENSGALP00000070206 | Apolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons, VLDL and LDL. It functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | 0.401 |
APOB | CYP1A1 | ENSGALP00000026550 | ENSGALP00000039219 | Apolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons, VLDL and LDL. It functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.406 |
APOB | ESR1 | ENSGALP00000026550 | ENSGALP00000073938 | Apolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons, VLDL and LDL. It functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.473 |
APOB | ESR2 | ENSGALP00000026550 | ENSGALP00000019234 | Apolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons, VLDL and LDL. It functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Estrogen receptor beta; Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Belongs to the nuclear hormone receptor family. NR3 subfamily. | 0.428 |
AR | CCND1 | ENSGALP00000046062 | ENSGALP00000012203 | Uncharacterized protein. | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). | 0.786 |
AR | CDK2 | ENSGALP00000046062 | ENSGALP00000056613 | Uncharacterized protein. | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.448 |
AR | CDK6 | ENSGALP00000046062 | ENSGALP00000015412 | Uncharacterized protein. | Cyclin-dependent kinase; Belongs to the protein kinase superfamily. | 0.413 |
AR | CYP19A1 | ENSGALP00000046062 | ENSGALP00000066452 | Uncharacterized protein. | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | 0.791 |
AR | ESR1 | ENSGALP00000046062 | ENSGALP00000073938 | Uncharacterized protein. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.812 |
AR | ESR2 | ENSGALP00000046062 | ENSGALP00000019234 | Uncharacterized protein. | Estrogen receptor beta; Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Belongs to the nuclear hormone receptor family. NR3 subfamily. | 0.606 |
CCND1 | AR | ENSGALP00000012203 | ENSGALP00000046062 | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). | Uncharacterized protein. | 0.786 |
CCND1 | CDK2 | ENSGALP00000012203 | ENSGALP00000056613 | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.965 |
CCND1 | CDK6 | ENSGALP00000012203 | ENSGALP00000015412 | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). | Cyclin-dependent kinase; Belongs to the protein kinase superfamily. | 0.999 |
CCND1 | CYCS | ENSGALP00000012203 | ENSGALP00000017934 | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.681 |
CCND1 | CYP19A1 | ENSGALP00000012203 | ENSGALP00000066452 | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | 0.439 |
CCND1 | ESR1 | ENSGALP00000012203 | ENSGALP00000073938 | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.888 |
CCND1 | ESR2 | ENSGALP00000012203 | ENSGALP00000019234 | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). | Estrogen receptor beta; Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Belongs to the nuclear hormone receptor family. NR3 subfamily. | 0.553 |
CCND1 | PCNA | ENSGALP00000012203 | ENSGALP00000064149 | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.965 |