node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGRP | BDNF | ENSGALP00000003505 | ENSGALP00000071950 | Agouti-related protein. | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | 0.549 |
AGRP | CCK | ENSGALP00000003505 | ENSGALP00000044506 | Agouti-related protein. | Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes. | 0.861 |
AGRP | CD320 | ENSGALP00000003505 | ENSGALP00000046844 | Agouti-related protein. | Uncharacterized protein. | 0.425 |
AGRP | CRH | ENSGALP00000003505 | ENSGALP00000050250 | Agouti-related protein. | Corticotropin releasing hormone. | 0.674 |
AGRP | CRHR1 | ENSGALP00000003505 | ENSGALP00000000502 | Agouti-related protein. | Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. | 0.484 |
AGRP | NPVF | ENSGALP00000003505 | ENSGALP00000037048 | Agouti-related protein. | Gonadotropin-inhibitory hormone. | 0.537 |
AGRP | NPY | ENSGALP00000003505 | ENSGALP00000017870 | Agouti-related protein. | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | 0.984 |
AGRP | POMC | ENSGALP00000003505 | ENSGALP00000063133 | Agouti-related protein. | Uncharacterized protein. | 0.985 |
AGRP | RAX | ENSGALP00000003505 | ENSGALP00000043973 | Agouti-related protein. | Retinal homeobox protein Rx2; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. | 0.675 |
AGRP | SST | ENSGALP00000003505 | ENSGALP00000011889 | Agouti-related protein. | Somatostatin-14; Somatostatin inhibits the release of somatotropin. | 0.515 |
AGRP | TH | ENSGALP00000003505 | ENSGALP00000051175 | Agouti-related protein. | Tyrosine hydroxylase. | 0.624 |
AGRP | TRH | ENSGALP00000003505 | ENSGALP00000013820 | Agouti-related protein. | Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems; Belongs to the TRH family. | 0.853 |
ALB | BDNF | ENSGALP00000044604 | ENSGALP00000071950 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | 0.748 |
ALB | CCK | ENSGALP00000044604 | ENSGALP00000044506 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. | Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes. | 0.682 |
ALB | NPY | ENSGALP00000044604 | ENSGALP00000017870 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | 0.484 |
ALB | NTRK2 | ENSGALP00000044604 | ENSGALP00000069010 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. | BDNF/NT-3 growth factors receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, [...] | 0.486 |
ALB | POMC | ENSGALP00000044604 | ENSGALP00000063133 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. | Uncharacterized protein. | 0.579 |
ALB | SST | ENSGALP00000044604 | ENSGALP00000011889 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. | Somatostatin-14; Somatostatin inhibits the release of somatotropin. | 0.597 |
ALB | TH | ENSGALP00000044604 | ENSGALP00000051175 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. | Tyrosine hydroxylase. | 0.679 |
BDNF | AGRP | ENSGALP00000071950 | ENSGALP00000003505 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Agouti-related protein. | 0.549 |