STRINGSTRING
FGF23 FGF23 CDH1 CDH1 SIRT1 SIRT1 TBC1D2B TBC1D2B LOC422993 LOC422993 SHH SHH UBE2I UBE2I FGF4 FGF4 FGF16 FGF16 NFATC2 NFATC2 CREB1 CREB1 CTLA4 CTLA4 VIM VIM FOSL2 FOSL2 KITLG KITLG GLI2 GLI2 HIF1A HIF1A TERT TERT FGF20 FGF20 MSX1 MSX1 CDH2 CDH2 PXDN PXDN FGF14 FGF14 SMAD9 SMAD9 TYR TYR FGF6 FGF6 POU2F1 POU2F1 CDH6 CDH6 MLANA MLANA FGF2 FGF2 FGF8 FGF8 DCT DCT TYRP1 TYRP1 SMAD5 SMAD5 FOS FOS FGF9 FGF9 FOXE3 FOXE3 FGF3 FGF3 LOC770612 LOC770612 FGF7 FGF7 FGF19 FGF19 NRAS NRAS LOC769000 LOC769000 CHTOP CHTOP TWIST1 TWIST1 KDM5B KDM5B LMO2 LMO2 FGF22 FGF22 GLI1 GLI1 PXDNL PXDNL HGF HGF SMAD1 SMAD1 MAP2K1 MAP2K1 FGF12 FGF12 KIT KIT CDYL CDYL LCOR LCOR EGR3 EGR3 YAP1 YAP1 FGF13 FGF13 SMAD7 SMAD7 SRF SRF FGF18 FGF18 SMAD2Z SMAD2Z DNMT1 DNMT1 SMAD7B SMAD7B CD44 CD44 PAX3 PAX3 EPAS1 EPAS1 HDAC1 HDAC1 ACTB ACTB SMARCA4 SMARCA4 FGF10 FGF10 CTBP1 CTBP1 FGF5 FGF5 CD4 CD4 ACTA2 ACTA2 RXRG RXRG EHMT1 EHMT1 GPX4 GPX4 LOC112530287 LOC112530287 MITF MITF S100A16 S100A16 ZEB2 ZEB2 PIK3C3 PIK3C3 FGF11 FGF11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (254 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha- E/beta-7. (887 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (881 aa)
TBC1D2BTBC1 domain family member 2B. (828 aa)
LOC422993Interferon-inducible transmembrane protein 1. (113 aa)
SHHSonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa)
UBE2ISUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
FGF4Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb development during embryogenesis (By similarity). (194 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
NFATC2Nuclear factor of activated T cells 2. (927 aa)
CREB1cAMP response element-binding protein. (327 aa)
CTLA4Cytotoxic T-lymphocyte-associated protein 4. (205 aa)
VIMVimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (460 aa)
FOSL2Fos-related antigen 2. (323 aa)
KITLGProcessed kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Acts synergistically with other cytokines, probably interleukins (By similarity). (287 aa)
GLI2Zinc finger protein GLI2; Functions as transcription regulator in the hedgehog (Hh) pathway. Functions as transcriptional activator. May also function as transcriptional repressor. Binds to the DNA sequence 5'-GAACCACCCA-3' (By similarity). Is involved in the smoothened (SHH) signaling pathway. Required for normal skeleton development (By similarity). (1528 aa)
HIF1AHypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators (By similarity). (811 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1346 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MSX1Homeobox protein GHOX-7; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death. (288 aa)
CDH2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). (912 aa)
PXDNPeroxidasin. (1611 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (253 aa)
SMAD9Mothers against decapentaplegic homolog. (476 aa)
TYRTyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. (537 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
POU2F1POU domain, class 2, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). (766 aa)
CDH6Cadherin-6; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. (790 aa)
MLANAMelan-A. (113 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. (158 aa)
FGF8Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
DCTL-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. (521 aa)
TYRP15,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. (536 aa)
SMAD5Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor- regulated SMAD (R-SMAD) (By similarity). (465 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, may activate phospholipid synthesis (By similarity). (367 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
FOXE3Forkhead box protein D3; Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri- implantation stages of embryogenesis. (386 aa)
FGF3Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (220 aa)
LOC770612Uncharacterized protein. (137 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
LOC769000Mothers against decapentaplegic homolog. (467 aa)
CHTOPMothers against decapentaplegic homolog. (445 aa)
TWIST1CTwist. (190 aa)
KDM5BLysine-specific demethylase 5B; Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor. May repress the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. (1616 aa)
LMO2LIM domain only 2. (216 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (176 aa)
GLI1Zinc finger protein GLI1; Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3' (By similarity). May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling. Belongs to the GLI C2H2-type zinc-finger protein family. (1281 aa)
PXDNLUncharacterized protein. (1406 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (726 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...] (960 aa)
CDYLChromo domain-containing protein. (871 aa)
LCORLigand dependent nuclear receptor corepressor. (1734 aa)
EGR3Early growth response 3. (396 aa)
YAP1Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation (By similarity); Belongs to the YAP1 family. (500 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
SMAD7Mothers against decapentaplegic homolog. (388 aa)
SRFSerum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. (492 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SMAD2ZMothers against decapentaplegic homolog. (467 aa)
DNMT1DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. Mediates transcriptional repression by direct binding to HDAC2. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their [...] (1417 aa)
SMAD7BMothers against decapentaplegic homolog. (388 aa)
CD44Link domain-containing protein. (696 aa)
PAX3Paired-box transcription factor protein PAX3. (484 aa)
EPAS1Endothelial PAS domain protein 1. (867 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. (480 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
SMARCA4Uncharacterized protein. (1178 aa)
FGF10Uncharacterized protein. (261 aa)
CTBP1Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (447 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (292 aa)
CD4Uncharacterized protein. (487 aa)
ACTA2Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (377 aa)
RXRGRetinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). (469 aa)
EHMT1Uncharacterized protein. (1325 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
LOC112530287Mothers against decapentaplegic homolog. (343 aa)
MITFBHLH domain-containing protein. (519 aa)
S100A16Protein S100; Belongs to the S-100 family. (108 aa)
ZEB2Smad-interacting protein 1. (1214 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (944 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.