Your Input: | |
| | RAD51 | DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. (339 aa) |
| | RELA | Transcription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites tha [...] (559 aa) |
| | GNMT | Methyltransf_25 domain-containing protein. (172 aa) |
| | CNPY3 | Canopy FGF signaling regulator 3. (253 aa) |
| | ZNF622 | Zinc finger protein 622; May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development. (469 aa) |
| | TACR1 | Substance P receptor; Belongs to the G-protein coupled receptor 1 family. (411 aa) |
| | PTGES2 | Prostaglandin E synthase 2; Belongs to the GST superfamily. (350 aa) |
| | CNOT11 | CCR4-NOT transcription complex subunit 11. (473 aa) |
| | UBL7 | Uncharacterized protein. (380 aa) |
| | CD48 | CD48. (249 aa) |
| | BLB2 | MHC class II beta chain 2. (263 aa) |
| | DHX36 | DEAH-box helicase 36. (987 aa) |
| | RBM14 | RNA binding motif protein 14. (750 aa) |
| | KCNA3 | BTB domain-containing protein; Belongs to the potassium channel family. (580 aa) |
| | ZNRF2 | Zinc and ring finger 2. (232 aa) |
| | YTHDF2 | YTH N6-methyladenosine RNA binding protein 2. (645 aa) |
| | IGF2BP1 | Insulin-like growth factor 2 mRNA-binding protein 1; RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta- actin/AC [...] (575 aa) |
| | NCOR1 | Uncharacterized protein. (440 aa) |
| | NFIX | Nuclear factor 1 X-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (501 aa) |
| | CREBBP | CREB binding protein. (2522 aa) |
| | RBM10 | Uncharacterized protein. (911 aa) |
| | DDX49 | Uncharacterized protein; Belongs to the DEAD box helicase family. (479 aa) |
| | GLB1 | Beta-galactosidase. (652 aa) |
| | NUP153 | Nucleoporin 153. (1455 aa) |
| | ERAL1 | GTPase Era, mitochondrial; Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family. (526 aa) |
| | GLB1L2 | Beta-galactosidase. (656 aa) |
| | MCRS1 | Microspherule protein 1. (513 aa) |
| | PLRG1 | Pleiotropic regulator 1. (516 aa) |
| | STMN1 | Stathmin; Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules (By similarity). (172 aa) |
| | RBL2 | Uncharacterized protein. (1259 aa) |
| | MRPS7 | 28S ribosomal protein S7, mitochondrial; Belongs to the universal ribosomal protein uS7 family. (243 aa) |
| | UBE2V2 | Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity); Belongs to the ubiquitin-c [...] (229 aa) |
| | CD4 | Uncharacterized protein. (487 aa) |
| | LAMA2 | Uncharacterized protein. (598 aa) |
| | GAPVD1 | Uncharacterized protein. (1488 aa) |
| | PNPLA6 | Uncharacterized protein. (1435 aa) |
| | OSBPL7 | Oxysterol-binding protein; Belongs to the OSBP family. (901 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa) |
| | TRMT11 | tRNA (guanine(10)-N2)-methyltransferase homolog; Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs. (468 aa) |
| | CLTA | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (245 aa) |
| | CDK14 | Cyclin dependent kinase 14; Belongs to the protein kinase superfamily. (469 aa) |
| | UBR2 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1758 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (909 aa) |
| | CTTN | Src substrate protein p85; Contributes to the organization of the actin cytoskeleton and cell shape (By similarity). Plays a role in the formation of lamellipodia and in cell migration (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones, and may play a role in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cel [...] (516 aa) |
| | PRMT7 | Protein arginine N-methyltransferase 7; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being [...] (689 aa) |
| | RAB44 | Uncharacterized protein. (1276 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa) |
| | CSTF2 | RRM domain-containing protein. (573 aa) |
| | ZYX | Zyxin; Adhesion plaque protein. Binds alpha-actinin and the CRP protein. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression. (602 aa) |
| | ARID4A | ARID domain-containing protein. (1252 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (781 aa) |
| | HYAL1 | Hyaluronidase. (436 aa) |
| | NSUN5 | NOP2/Sun RNA methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (465 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa) |
| | RCC1L | Uncharacterized protein. (454 aa) |
| | CWC25 | CWC25 spliceosome associated protein homolog. (416 aa) |
| | FBXL20 | F-box and leucine rich repeat protein 20. (436 aa) |
| | NUP35 | Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (325 aa) |
| | XRN1 | 5'-3' exoribonuclease 1. (1770 aa) |
| | AARSD1 | AA_TRNA_LIGASE_II_ALA domain-containing protein. (409 aa) |
| | BCR | BCR activator of RhoGEF and GTPase. (1351 aa) |
| | LBP | Uncharacterized protein. (481 aa) |
| | TLR4 | Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa) |
| | PCNT | Pericentrin. (3492 aa) |
| | PIAS1 | Uncharacterized protein. (727 aa) |
| | DDB2 | DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1- CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1- CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV [...] (507 aa) |
| | CREB1 | cAMP response element-binding protein. (327 aa) |
| | SMNDC1 | Survival motor neuron domain containing 1. (238 aa) |
| | HAUS2 | Uncharacterized protein. (252 aa) |
| | TIE1 | Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1140 aa) |
| | CNOT2 | NOT2_3_5 domain-containing protein. (520 aa) |
| | SNX13 | Uncharacterized protein. (969 aa) |
| | CEP290 | Uncharacterized protein. (553 aa) |
| | PLEKHA8 | Pleckstrin homology domain containing A8. (522 aa) |
| | GLB1L | Galactosidase beta 1 like; Belongs to the glycosyl hydrolase 35 family. (633 aa) |
| | PHF5A | Uncharacterized protein. (110 aa) |
| | RPL7L1 | Uncharacterized protein. (247 aa) |
| | ZNF148 | Zinc finger protein 148. (774 aa) |
| | ELP4 | Elongator acetyltransferase complex subunit 4. (545 aa) |
| | IRF4 | Interferon regulatory factor 4. (445 aa) |
| | KDM5A | Lysine demethylase 5A. (1692 aa) |
| | FIP1L1 | Fip1 domain-containing protein. (545 aa) |
| | DHX29 | ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily. (1372 aa) |
| | CD274 | Uncharacterized protein. (471 aa) |
| | SMC5 | Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; [...] (1065 aa) |
| | CD247 | Uncharacterized protein. (166 aa) |
| | ASCC3 | Activating signal cointegrator 1 complex subunit 3; 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. (2211 aa) |
| | MRPL50 | 39S ribosomal protein L50, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL50 family. (163 aa) |
| | PTCD3 | Pentatricopeptide repeat domain 3. (428 aa) |
| | MX1 | Interferon-induced GTP-binding protein Mx; Does not show activity against influenza virus, VSV, Thogoto virus or Sendai virus. (705 aa) |
| | INTS9 | Integrator complex subunit 9; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'- box-dependent processing; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. INTS9 subfamily. (658 aa) |
| | IL17A | Uncharacterized protein. (169 aa) |
| | TFDP1 | Transcription factor. (411 aa) |
| | LMO7 | LIM domain 7. (1608 aa) |
| | PCF11 | PCF11 cleavage and polyadenylation factor subunit. (1690 aa) |
| | HBBR | Hemoglobin subunit rho; The rho chain is the major early embryonic beta-type hemoglobin chain. (147 aa) |
| | MRPL30 | Ribosomal_L30 domain-containing protein. (166 aa) |
| | ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (342 aa) |
| | RNF7 | RING-type domain-containing protein. (114 aa) |
| | MATN3 | Matrilin-3; Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks. (452 aa) |
| | POLR2B | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa) |
| | RPL19 | Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. (196 aa) |
| | DDX20 | DEAD-box helicase 20; Belongs to the DEAD box helicase family. (767 aa) |
| | NEK7 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa) |
| | PRPF3 | U4/U6 small nuclear ribonucleoprotein Prp3; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). (684 aa) |
| | NWD1 | WD_REPEATS_REGION domain-containing protein. (425 aa) |
| | SYT1 | Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. May play a role in dendrite formation by melanocytes; Belongs to the synaptotagmin family. (430 aa) |
| | CATH1 | Cathelicidin-1; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response. (148 aa) |
| | ANKRD27 | Uncharacterized protein. (1087 aa) |
| | CDC42SE2 | CRIB domain-containing protein. (84 aa) |
| | HNMT | Uncharacterized protein. (317 aa) |
| | YTHDF3 | YTH domain-containing protein. (593 aa) |
| | EPB41L2 | 4_1_CTD domain-containing protein. (129 aa) |
| | MRPS14 | Uncharacterized protein. (126 aa) |
| | TFEB | BHLH domain-containing protein. (493 aa) |
| | MRPS18A | Uncharacterized protein. (144 aa) |
| | STAT1 | Signal transducer and activator of transcription. (755 aa) |
| | INTS8 | Uncharacterized protein. (995 aa) |
