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CACUL1 CACUL1 LPO LPO HMGB1 HMGB1 NOS3 NOS3 FYN FYN GPX4 GPX4 IL6 IL6 NCK1 NCK1 SMARCA4 SMARCA4 KRT14 KRT14 SMAD3 SMAD3 KRT17 KRT17 NOS1 NOS1 PTGS2 PTGS2 NR3C1 NR3C1 COL3A1 COL3A1 SIRT1 SIRT1 UGT1A1 UGT1A1 CUL3 CUL3 GPX7 GPX7 CRYZ CRYZ SOD2 SOD2 UGT2A1 UGT2A1 IL2 IL2 RBX1 RBX1 MT3 MT3 BACH1 BACH1 GCLC GCLC HMOX1 HMOX1 GPX8 GPX8 GPX1 GPX1 MT4 MT4 CAV1 CAV1 SIRT2 SIRT2 STAT1 STAT1 CUL1 CUL1 IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CACUL1Cullin domain-containing protein; Belongs to the cullin family. (377 aa)
LPOUncharacterized protein. (790 aa)
HMGB1High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Can restructure the canonical nucleosome. Proposed to be an universal biosensor for nucle [...] (215 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1402 aa)
FYNTyrosine-protein kinase Fyn; Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling. (589 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
NCK1Cytoplasmic protein. (380 aa)
SMARCA4Uncharacterized protein. (1178 aa)
KRT14Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. (467 aa)
SMAD3Mothers against decapentaplegic homolog 3; Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor- regulated SMAD (R-SMAD) (By similarity). (426 aa)
KRT17IF rod domain-containing protein; Belongs to the intermediate filament family. (559 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1435 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (652 aa)
NR3C1Uncharacterized protein. (837 aa)
COL3A1Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (881 aa)
UGT1A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (532 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (210 aa)
CRYZPKS_ER domain-containing protein. (331 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
UGT2A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
IL2Interleukin; Belongs to the IL-15/IL-21 family. (143 aa)
RBX1RING-type domain-containing protein. (108 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (63 aa)
BACH1BTB domain and CNC homolog 1. (675 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (636 aa)
HMOX1Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. (317 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (210 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (182 aa)
MT4Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals; Belongs to the metallothionein superfamily. Type 1 family. (63 aa)
CAV1Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa)
SIRT2Deacetylase sirtuin-type domain-containing protein. (485 aa)
STAT1Signal transducer and activator of transcription. (755 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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