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NEUROD1 NEUROD1 SNAI1 SNAI1 FGF16 FGF16 ZEB1 ZEB1 FGF22 FGF22 POU4F1 POU4F1 SIX1 SIX1 HAND2 HAND2 SOX2 SOX2 SOX5 SOX5 FGF19 FGF19 ISL1 ISL1 PRDM1 PRDM1 FGF11 FGF11 MYC MYC FGF7 FGF7 FGF23 FGF23 FOXE3 FOXE3 FGF9 FGF9 SOX9 SOX9 EDNRB EDNRB EYA2 EYA2 SIX4 SIX4 FGF6 FGF6 FGF14 FGF14 MSX1 MSX1 FGF20 FGF20 TFAP2A TFAP2A FGF12 FGF12 EYA1 EYA1 COL2A1 COL2A1 FGF13 FGF13 ZIC1 ZIC1 FGF18 FGF18 SNAI2 SNAI2 PAX3 PAX3 NEUROG1 NEUROG1 FGF10 FGF10 FGF5 FGF5 DLX3 DLX3 MITF MITF PAX6 PAX6 ZEB2 ZEB2 CXCR4 CXCR4 SOX10 SOX10
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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NEUROD1Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa)
SNAI1Snail like protein. (256 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ZEB1Zinc finger E-box-binding homeobox 1; Acts as a transcriptional repressor. Positively regulates neuronal differentiation. Represses transcription by binding to the E box-containing promoter (By similarity). Binds to delta 1-crystallin enhancer core and represses lens-specific transcription. It binds as well many other non-lens specific DNA sequences. (1114 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (176 aa)
POU4F1POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...] (389 aa)
SIX1Sine oculis-related homeobox 1 homolog. (282 aa)
HAND2Heart- and neural crest derivatives-expressed protein 2; Essential for cardiac morphogenesis. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). Plays an important role in limb development, particularly in the establishment of anterior-posterior polarization of the limb bud. (216 aa)
SOX2Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa)
SOX5Transcription factor LSox5-II. (772 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
ISL1Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa)
PRDM1PR/SET domain 1. (789 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (254 aa)
FOXE3Forkhead box protein D3; Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri- implantation stages of embryogenesis. (386 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
EDNRBG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (560 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (631 aa)
SIX4SIX homeobox 4. (776 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (253 aa)
MSX1Homeobox protein GHOX-7; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death. (288 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
TFAP2ATF_AP-2 domain-containing protein. (437 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
EYA1Eyes absent homolog 1; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for other transcription factors of this family. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function i [...] (625 aa)
COL2A1Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. (1420 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
ZIC1Zinc finger protein ZIC 1; Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity). (444 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SNAI2Uncharacterized protein. (258 aa)
PAX3Paired-box transcription factor protein PAX3. (484 aa)
NEUROG1Neurogenin 1. (179 aa)
FGF10Uncharacterized protein. (261 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (292 aa)
DLX3Homeobox domain-containing protein. (451 aa)
MITFBHLH domain-containing protein. (519 aa)
PAX6Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development. (500 aa)
ZEB2Smad-interacting protein 1. (1214 aa)
CXCR4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
SOX10Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. (461 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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