14 items (Gallus gallus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	SLC45A2	Uncharacterized protein. (543 aa)
	IL18	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. (198 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (586 aa)
	SOX10	Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. (461 aa)
	TYR	Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. (537 aa)
	CD86	Uncharacterized protein. (319 aa)
	TYRP1	5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. (536 aa)
	IFNW1	Interferon type B; Has antiviral activities; Belongs to the alpha/beta interferon family. (203 aa)
	ATG10	Autophagy related 10. (227 aa)
	SOX5	Transcription factor LSox5-II. (772 aa)
	PMEL	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family. (740 aa)
	EDN3	Endothelin 3. (151 aa)
	IFNA3	Interferon. (193 aa)
	MC1R	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family. (314 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD86	IFNA3	ENSGALP00000036384	ENSGALP00000070204	Uncharacterized protein.	Interferon.	0.710
CD86	IL18	ENSGALP00000036384	ENSGALP00000012772	Uncharacterized protein.	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	0.708
EDN3	MC1R	ENSGALP00000056488	ENSGALP00000071620	Endothelin 3.	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	0.752
EDN3	PMEL	ENSGALP00000056488	ENSGALP00000051268	Endothelin 3.	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family.	0.519
EDN3	SOX10	ENSGALP00000056488	ENSGALP00000020056	Endothelin 3.	Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination.	0.845
EDN3	SOX5	ENSGALP00000056488	ENSGALP00000043607	Endothelin 3.	Transcription factor LSox5-II.	0.555
EDN3	TYR	ENSGALP00000056488	ENSGALP00000027812	Endothelin 3.	Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.	0.717
EDN3	TYRP1	ENSGALP00000056488	ENSGALP00000037537	Endothelin 3.	5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.	0.709
IFNA3	CD86	ENSGALP00000070204	ENSGALP00000036384	Interferon.	Uncharacterized protein.	0.710
IFNA3	IL18	ENSGALP00000070204	ENSGALP00000012772	Interferon.	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	0.844
IFNW1	IL18	ENSGALP00000038687	ENSGALP00000012772	Interferon type B; Has antiviral activities; Belongs to the alpha/beta interferon family.	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	0.742
IL18	CD86	ENSGALP00000012772	ENSGALP00000036384	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	Uncharacterized protein.	0.708
IL18	IFNA3	ENSGALP00000012772	ENSGALP00000070204	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	Interferon.	0.844
IL18	IFNW1	ENSGALP00000012772	ENSGALP00000038687	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	Interferon type B; Has antiviral activities; Belongs to the alpha/beta interferon family.	0.742
MC1R	EDN3	ENSGALP00000071620	ENSGALP00000056488	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	Endothelin 3.	0.752
MC1R	PMEL	ENSGALP00000071620	ENSGALP00000051268	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family.	0.751
MC1R	SLC45A2	ENSGALP00000071620	ENSGALP00000005236	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.861
MC1R	SOX10	ENSGALP00000071620	ENSGALP00000020056	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination.	0.556
MC1R	TYR	ENSGALP00000071620	ENSGALP00000027812	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.	0.919
MC1R	TYRP1	ENSGALP00000071620	ENSGALP00000037537	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.	0.904