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ABCA12 ABCA12 MGST3 MGST3 CYP1A2 CYP1A2 PAK1 PAK1 STAT3 STAT3 LPO LPO NFE2L2 NFE2L2 STAT6 STAT6 SRXN1 SRXN1 ME1 ME1 GPX4 GPX4 IL6 IL6 LY96 LY96 CTSS CTSS MGST1 MGST1 AIF1L AIF1L TXNRD1 TXNRD1 ENPP2 ENPP2 PTGS2 PTGS2 CTSH CTSH CAPN5 CAPN5 CTSZ CTSZ IL1B IL1B IRF5 IRF5 GSTM2 GSTM2 IGF2 IGF2 CYP1B1 CYP1B1 PRDX1 PRDX1 GSTM3 GSTM3 GSR GSR ALB ALB CSF3 CSF3 IL34 IL34 NFKB2 NFKB2 GPX1 GPX1 FTL FTL GADD45G GADD45G GPX8 GPX8 TCIM TCIM CYP1A1 CYP1A1 FAS FAS ASS1 ASS1 ABCB1-2 ABCB1-2 NFKB1 NFKB1 PLA2R1 PLA2R1 CTSC CTSC IL17A IL17A RSAD2 RSAD2 GSTA2 GSTA2 GSTA3 GSTA3 GSTA4 GSTA4 GCLC GCLC CYP26B1 CYP26B1 TXN TXN ABCA1 ABCA1 GLRX GLRX C1S C1S CTSV CTSV TNFAIP6 TNFAIP6 CRYZ CRYZ KITLG KITLG GPX7 GPX7 HPGDS HPGDS EPHX1L EPHX1L MDM2 MDM2 ARG2 ARG2 EPHX1 EPHX1 ITGB2 ITGB2 RPLP0 RPLP0 CYP3A4 CYP3A4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABCA12ATP binding cassette subfamily A member 12. (3348 aa)
MGST3Uncharacterized protein. (142 aa)
CYP1A2Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
STAT3Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa)
LPOUncharacterized protein. (790 aa)
NFE2L2BZIP domain-containing protein. (593 aa)
STAT6SH2 domain-containing protein. (183 aa)
SRXN1Sulfiredoxin. (155 aa)
ME1Malic enzyme. (655 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
LY96Lymphocyte antigen 96. (155 aa)
CTSSUncharacterized protein; Belongs to the peptidase C1 family. (508 aa)
MGST1Uncharacterized protein. (155 aa)
AIF1LAllograft inflammatory factor 1-like protein. (145 aa)
TXNRD1Uncharacterized protein. (530 aa)
ENPP2Uncharacterized protein. (859 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (652 aa)
CTSHUncharacterized protein; Belongs to the peptidase C1 family. (403 aa)
CAPN5Calpain 5; Belongs to the peptidase C2 family. (641 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (325 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
IRF5IRF tryptophan pentad repeat domain-containing protein. (472 aa)
GSTM2Glutathione S-transferase 2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family. (220 aa)
IGF2Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling. (187 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (536 aa)
PRDX1Peroxiredoxin-1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron diffe [...] (199 aa)
GSTM3Glutathione S-transferase. (219 aa)
GSRGlutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (464 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. (565 aa)
CSF3Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily. (201 aa)
IL34Interleukin 34. (178 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the indi [...] (913 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (182 aa)
FTLFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (278 aa)
GADD45GGrowth arrest and DNA-damage-inducible protein 45 gamma. (159 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (210 aa)
TCIMTranscriptional and immune response regulator. (106 aa)
CYP1A1Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
FASUncharacterized protein. (339 aa)
ASS1Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues; Belongs to the argininosuccinate synthase family. (416 aa)
ABCB1-2Multidrug resistance protein 1. (1288 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit; P105 is the precursor of the p50 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'- GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. The precursor protein itself does not bind to DNA. (983 aa)
PLA2R1Uncharacterized protein. (1459 aa)
CTSCPept_C1 domain-containing protein; Belongs to the peptidase C1 family. (532 aa)
IL17AUncharacterized protein. (169 aa)
RSAD2Viperin. (354 aa)
GSTA2Glutathione S-transferase; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family. (222 aa)
GSTA3Glutathione S-transferase; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. (221 aa)
GSTA4Glutathione S-transferase class-alpha. (223 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (636 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa)
TXNThioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (105 aa)
ABCA1Uncharacterized protein. (2260 aa)
GLRXGlutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family. (101 aa)
C1SUncharacterized protein; Belongs to the peptidase S1 family. (701 aa)
CTSVCathepsin L1 heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. (353 aa)
TNFAIP6Tumor necrosis factor-inducible protein 6. (275 aa)
CRYZPKS_ER domain-containing protein. (331 aa)
KITLGProcessed kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Acts synergistically with other cytokines, probably interleukins (By similarity). (287 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (210 aa)
HPGDSHematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide. (199 aa)
EPHX1LEHN domain-containing protein. (486 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (483 aa)
ARG2Arginase. (356 aa)
EPHX1Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. (464 aa)
ITGB2Integrin beta. (773 aa)
RPLP060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10; Belongs to the universal ribosomal protein uL10 family. (350 aa)
CYP3A4Uncharacterized protein; Belongs to the cytochrome P450 family. (540 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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