(21 nodes) (2020) Etiopathogenesis, Challenges and Remedies Associated With Female Genital Tuberculosis: Potential Role of Nuclear Receptors. network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (651 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
	CD4	Uncharacterized protein. (487 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (498 aa)
	AMH	TGF_BETA_2 domain-containing protein. (644 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
	CDH1	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha- E/beta-7. (887 aa)
	STAT3	Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa)
	NR2F2	COUP transcription factor 2; Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro) (By similarity). May be involved in motor neuron development. Belongs to the nuclear hormone receptor family. NR2 subfamily. (410 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (164 aa)
	NR1H4	Farnesoid X receptor. (473 aa)
	ESR2	Estrogen receptor beta; Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Belongs to the nuclear hormone receptor family. NR3 subfamily. (472 aa)
	IL2	Interleukin; Belongs to the IL-15/IL-21 family. (143 aa)
	IL17A	Uncharacterized protein. (169 aa)
	PGR	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (787 aa)
	OVAL	Ovalbumin; Non-inhibitory serpin. Storage protein of egg white. (386 aa)
	IL4	Interleukin 4. (136 aa)
	AR	Uncharacterized protein. (703 aa)
	RXRA	Retinoid X receptor alpha. (467 aa)
	GNLY	NK-lysin. (140 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMH	AR	ENSGALP00000051831	ENSGALP00000046062	TGF_BETA_2 domain-containing protein.	Uncharacterized protein.	0.795
AMH	ESR1	ENSGALP00000051831	ENSGALP00000073938	TGF_BETA_2 domain-containing protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.635
AMH	ESR2	ENSGALP00000051831	ENSGALP00000019234	TGF_BETA_2 domain-containing protein.	Estrogen receptor beta; Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.557
AR	AMH	ENSGALP00000046062	ENSGALP00000051831	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.795
AR	CDH1	ENSGALP00000046062	ENSGALP00000000855	Uncharacterized protein.	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha- E/beta-7.	0.501
AR	ESR1	ENSGALP00000046062	ENSGALP00000073938	Uncharacterized protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.812
AR	ESR2	ENSGALP00000046062	ENSGALP00000019234	Uncharacterized protein.	Estrogen receptor beta; Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.606
AR	PGR	ENSGALP00000046062	ENSGALP00000027736	Uncharacterized protein.	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.617
AR	STAT3	ENSGALP00000046062	ENSGALP00000005161	Uncharacterized protein.	Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes.	0.683
CD4	CDH1	ENSGALP00000065611	ENSGALP00000000855	Uncharacterized protein.	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha- E/beta-7.	0.471
CD4	ESR1	ENSGALP00000065611	ENSGALP00000073938	Uncharacterized protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.458
CD4	GNLY	ENSGALP00000065611	ENSGALP00000048071	Uncharacterized protein.	NK-lysin.	0.558
CD4	IFNG	ENSGALP00000065611	ENSGALP00000016086	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.989
CD4	IL10	ENSGALP00000065611	ENSGALP00000001310	Uncharacterized protein.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.982
CD4	IL17A	ENSGALP00000065611	ENSGALP00000026862	Uncharacterized protein.	Uncharacterized protein.	0.981
CD4	IL1B	ENSGALP00000065611	ENSGALP00000050171	Uncharacterized protein.	Interleukin-1; Belongs to the IL-1 family.	0.957
CD4	IL2	ENSGALP00000065611	ENSGALP00000019308	Uncharacterized protein.	Interleukin; Belongs to the IL-15/IL-21 family.	0.974
CD4	IL4	ENSGALP00000065611	ENSGALP00000039130	Uncharacterized protein.	Interleukin 4.	0.979
CD4	IL6	ENSGALP00000065611	ENSGALP00000068117	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.982
CD4	OVAL	ENSGALP00000065611	ENSGALP00000036403	Uncharacterized protein.	Ovalbumin; Non-inhibitory serpin. Storage protein of egg white.	0.979