(6 nodes) (2020) Comparing and Contrasting MERS, SARS-CoV, and SARS-CoV-2: Prevention, Transmission, Management, and Vaccine Development. network (Gallus gallus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	REN	Renin; Belongs to the peptidase A1 family. (423 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
	DPP4	Uncharacterized protein; Belongs to the peptidase S9B family. (760 aa)
	ACE	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. (1281 aa)
	PPP1CB	Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity; Belongs to the PPP phosphatase family. PP-1 subfamily. (327 aa)
	ACE2	Angiotensin-converting enzyme. (808 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	ACE2	ENSGALP00000039731	ENSGALP00000026662	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	Angiotensin-converting enzyme.	0.605
ACE	DPP4	ENSGALP00000039731	ENSGALP00000052897	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	Uncharacterized protein; Belongs to the peptidase S9B family.	0.720
ACE	IL6	ENSGALP00000039731	ENSGALP00000068117	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.729
ACE	REN	ENSGALP00000039731	ENSGALP00000000756	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	Renin; Belongs to the peptidase A1 family.	0.981
ACE2	ACE	ENSGALP00000026662	ENSGALP00000039731	Angiotensin-converting enzyme.	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	0.605
ACE2	DPP4	ENSGALP00000026662	ENSGALP00000052897	Angiotensin-converting enzyme.	Uncharacterized protein; Belongs to the peptidase S9B family.	0.984
ACE2	IL6	ENSGALP00000026662	ENSGALP00000068117	Angiotensin-converting enzyme.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.855
ACE2	REN	ENSGALP00000026662	ENSGALP00000000756	Angiotensin-converting enzyme.	Renin; Belongs to the peptidase A1 family.	0.981
DPP4	ACE	ENSGALP00000052897	ENSGALP00000039731	Uncharacterized protein; Belongs to the peptidase S9B family.	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	0.720
DPP4	ACE2	ENSGALP00000052897	ENSGALP00000026662	Uncharacterized protein; Belongs to the peptidase S9B family.	Angiotensin-converting enzyme.	0.984
DPP4	IL6	ENSGALP00000052897	ENSGALP00000068117	Uncharacterized protein; Belongs to the peptidase S9B family.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.586
DPP4	PPP1CB	ENSGALP00000052897	ENSGALP00000031272	Uncharacterized protein; Belongs to the peptidase S9B family.	Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity; Belongs to the PPP phosphatase family. PP-1 subfamily.	0.504
DPP4	REN	ENSGALP00000052897	ENSGALP00000000756	Uncharacterized protein; Belongs to the peptidase S9B family.	Renin; Belongs to the peptidase A1 family.	0.506
IL6	ACE	ENSGALP00000068117	ENSGALP00000039731	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	0.729
IL6	ACE2	ENSGALP00000068117	ENSGALP00000026662	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	Angiotensin-converting enzyme.	0.855
IL6	DPP4	ENSGALP00000068117	ENSGALP00000052897	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	Uncharacterized protein; Belongs to the peptidase S9B family.	0.586
IL6	REN	ENSGALP00000068117	ENSGALP00000000756	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	Renin; Belongs to the peptidase A1 family.	0.608
PPP1CB	DPP4	ENSGALP00000031272	ENSGALP00000052897	Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity; Belongs to the PPP phosphatase family. PP-1 subfamily.	Uncharacterized protein; Belongs to the peptidase S9B family.	0.504
REN	ACE	ENSGALP00000000756	ENSGALP00000039731	Renin; Belongs to the peptidase A1 family.	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	0.981
REN	ACE2	ENSGALP00000000756	ENSGALP00000026662	Renin; Belongs to the peptidase A1 family.	Angiotensin-converting enzyme.	0.981