STRINGSTRING
TIMP2 TIMP2 TMSB4X TMSB4X SOX9 SOX9 MMP13 MMP13 HIF1A HIF1A LUM LUM SPP1 SPP1 COL1A2 COL1A2 EGR1 EGR1 TNMD TNMD INS INS F1NWX5_CHICK F1NWX5_CHICK ASPN ASPN SPARC SPARC MTOR MTOR UQCRC2 UQCRC2 CASP9 CASP9 PPARG PPARG SIRT3 SIRT3 TMSB15B TMSB15B IL1B IL1B RUNX2 RUNX2 COL3A1 COL3A1 PTGS2 PTGS2 FOXO1 FOXO1 CD44 CD44 NOS1 NOS1 COL1A1 COL1A1 DCN DCN MKX MKX NOX4 NOX4 NOS3 NOS3 NOX1 NOX1 TMSB4Y TMSB4Y CMKLR1 CMKLR1 BMP2 BMP2 MMP9 MMP9 IL6 IL6 FMOD FMOD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TIMP2Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. (220 aa)
TMSB4XThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
MMP13ZnMc domain-containing protein. (530 aa)
HIF1AHypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators (By similarity). (811 aa)
LUMLumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (343 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (264 aa)
COL1A2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1363 aa)
EGR1Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (510 aa)
TNMDBRICHOS domain-containing protein. (319 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
F1NWX5_CHICKTGF_BETA_2 domain-containing protein. (367 aa)
ASPNAsporin. (371 aa)
SPARCSPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity). (298 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
UQCRC2Ubiquinol-cytochrome c reductase core protein 2. (457 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (418 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (498 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (347 aa)
TMSB15BThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
RUNX2Runt-related transcription factor. (472 aa)
COL3A1Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (652 aa)
FOXO1Fork-head domain-containing protein. (727 aa)
CD44Link domain-containing protein. (696 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1435 aa)
COL1A1Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1453 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (357 aa)
MKXMohawk homeobox. (350 aa)
NOX4FAD-binding FR-type domain-containing protein. (639 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1402 aa)
NOX1FAD-binding FR-type domain-containing protein. (564 aa)
TMSB4YThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
CMKLR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (360 aa)
BMP2Bone morphogenetic protein 2; Negatively regulates the structure and function of the limb apical ectodermal ridge. (392 aa)
MMP9Uncharacterized protein. (713 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
FMODFibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (380 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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