8 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CYP1A2	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
	ACHE	Acetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft; Belongs to the type-B carboxylesterase/lipase family. (767 aa)
	CNR1	Cannabinoid receptor; Involved in cannabinoid-induced CNS effects. Belongs to the G-protein coupled receptor 1 family. (495 aa)
	CYP2D6	Cytochrome P450 CYP2D49; Belongs to the cytochrome P450 family. (502 aa)
	PDE4B	Phosphodiesterase. (563 aa)
	CYP3A5	Uncharacterized protein. (508 aa)
	CYP3A4	Uncharacterized protein; Belongs to the cytochrome P450 family. (540 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP1A2	CYP3A4	ENSGALP00000002016	ENSGALP00000007048	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.966
CYP1A2	CYP3A5	ENSGALP00000002016	ENSGALP00000007068	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Uncharacterized protein.	0.973
CYP2D6	CYP3A4	ENSGALP00000019386	ENSGALP00000007048	Cytochrome P450 CYP2D49; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.711
CYP2D6	CYP3A5	ENSGALP00000019386	ENSGALP00000007068	Cytochrome P450 CYP2D49; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.713
CYP3A4	CYP1A2	ENSGALP00000007048	ENSGALP00000002016	Uncharacterized protein; Belongs to the cytochrome P450 family.	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.966
CYP3A4	CYP2D6	ENSGALP00000007048	ENSGALP00000019386	Uncharacterized protein; Belongs to the cytochrome P450 family.	Cytochrome P450 CYP2D49; Belongs to the cytochrome P450 family.	0.711
CYP3A4	CYP3A5	ENSGALP00000007048	ENSGALP00000007068	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.929
CYP3A5	CYP1A2	ENSGALP00000007068	ENSGALP00000002016	Uncharacterized protein.	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.973
CYP3A5	CYP2D6	ENSGALP00000007068	ENSGALP00000019386	Uncharacterized protein.	Cytochrome P450 CYP2D49; Belongs to the cytochrome P450 family.	0.713
CYP3A5	CYP3A4	ENSGALP00000007068	ENSGALP00000007048	Uncharacterized protein.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.929