27 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	MC4R	G_PROTEIN_RECEP_F1_2 domain-containing protein. (331 aa)
	NPY	C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa)
	MME	Neprilysin. (750 aa)
	CREB1	cAMP response element-binding protein. (327 aa)
	GHRL	Preproghrelin. (116 aa)
	SST	Somatostatin-14; Somatostatin inhibits the release of somatotropin. (116 aa)
	SYP	MARVEL domain-containing protein. (338 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
	ENSGALP00000070006	Synaptophysin. (351 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (498 aa)
	MMEL1	Membrane metalloendopeptidase like 1. (773 aa)
	MAPK3	Mitogen-activated protein kinase. (421 aa)
	GCG	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. (206 aa)
	ADIPOQ	C1q domain-containing protein. (244 aa)
	GH	Somatotropin; Growth hormone plays an important role in growth control. (216 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1402 aa)
	NOS1	Nitric oxide synthase; Produces nitric oxide (NO). (1435 aa)
	NPY2R	Neuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. (385 aa)
	POMC	Uncharacterized protein. (251 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	CCK	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes. (130 aa)
	MC3R	Melanocortin 3 receptor. (325 aa)
	GAL	Galanin variant 1. (141 aa)
	NTS	Neurotensin. (164 aa)
	FAM237A	Family with sequence similarity 237 member A. (182 aa)
	AGRP	Agouti-related protein. (233 aa)
	SPX	Spexin hormone. (116 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	AGRP	ENSGALP00000008899	ENSGALP00000003505	C1q domain-containing protein.	Agouti-related protein.	0.603
ADIPOQ	CCK	ENSGALP00000008899	ENSGALP00000044506	C1q domain-containing protein.	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.	0.485
ADIPOQ	GCG	ENSGALP00000008899	ENSGALP00000032494	C1q domain-containing protein.	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis.	0.629
ADIPOQ	GHRL	ENSGALP00000008899	ENSGALP00000013685	C1q domain-containing protein.	Preproghrelin.	0.750
ADIPOQ	IL1B	ENSGALP00000008899	ENSGALP00000050171	C1q domain-containing protein.	Interleukin-1; Belongs to the IL-1 family.	0.744
ADIPOQ	INS	ENSGALP00000008899	ENSGALP00000010567	C1q domain-containing protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.958
ADIPOQ	MC4R	ENSGALP00000008899	ENSGALP00000021014	C1q domain-containing protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.448
ADIPOQ	NPY	ENSGALP00000008899	ENSGALP00000017870	C1q domain-containing protein.	C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family.	0.523
ADIPOQ	POMC	ENSGALP00000008899	ENSGALP00000063133	C1q domain-containing protein.	Uncharacterized protein.	0.471
ADIPOQ	PPARG	ENSGALP00000008899	ENSGALP00000067699	C1q domain-containing protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.899
AGRP	ADIPOQ	ENSGALP00000003505	ENSGALP00000008899	Agouti-related protein.	C1q domain-containing protein.	0.603
AGRP	CCK	ENSGALP00000003505	ENSGALP00000044506	Agouti-related protein.	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.	0.861
AGRP	FAM237A	ENSGALP00000003505	ENSGALP00000032763	Agouti-related protein.	Family with sequence similarity 237 member A.	0.422
AGRP	GAL	ENSGALP00000003505	ENSGALP00000042337	Agouti-related protein.	Galanin variant 1.	0.588
AGRP	GCG	ENSGALP00000003505	ENSGALP00000032494	Agouti-related protein.	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis.	0.746
AGRP	GHRL	ENSGALP00000003505	ENSGALP00000013685	Agouti-related protein.	Preproghrelin.	0.982
AGRP	INS	ENSGALP00000003505	ENSGALP00000010567	Agouti-related protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.860
AGRP	MC3R	ENSGALP00000003505	ENSGALP00000042914	Agouti-related protein.	Melanocortin 3 receptor.	0.974
AGRP	MC4R	ENSGALP00000003505	ENSGALP00000021014	Agouti-related protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.990
AGRP	NOS1	ENSGALP00000003505	ENSGALP00000057794	Agouti-related protein.	Nitric oxide synthase; Produces nitric oxide (NO).	0.509