46 items (Gallus gallus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	FEZF2	FEZ family zinc finger 2. (441 aa)
	GNRH1	GnRH-associated peptide 1; Stimulates the secretion of gonadotropins; Belongs to the GnRH family. (92 aa)
	LHX2	LIM homeodomain. (400 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	NEUROD1	Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa)
	FEZF1	FEZ family zinc finger 1. (438 aa)
	DLX5	Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. (286 aa)
	GLI2	Zinc finger protein GLI2; Functions as transcription regulator in the hedgehog (Hh) pathway. Functions as transcriptional activator. May also function as transcriptional repressor. Binds to the DNA sequence 5'-GAACCACCCA-3' (By similarity). Is involved in the smoothened (SHH) signaling pathway. Required for normal skeleton development (By similarity). (1528 aa)
	BMP4	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. (404 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	FGF14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (253 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	SIX4	SIX homeobox 4. (776 aa)
	FGF8	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
	DICER1	Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] (1921 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	FGF23	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (254 aa)
	HES6-2	Uncharacterized protein. (227 aa)
	FGF3	Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (220 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	ISL1	Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
	NRP2	Uncharacterized protein. (969 aa)
	SLIT2	Uncharacterized protein. (1533 aa)
	SOX2	Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa)
	SIX1	Sine oculis-related homeobox 1 homolog. (282 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (176 aa)
	ASCL1	BHLH domain-containing protein. (219 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. (1576 aa)
	COL3A1	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa)
	FGF12	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
	TH	Tyrosine hydroxylase. (491 aa)
	TFAP2E	Transcription factor AP-2 epsilon. (541 aa)
	FGF13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	FOXG1	Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. (451 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	BCL11B	BAF chromatin remodeling complex subunit BCL11B. (884 aa)
	NEUROG1	Neurogenin 1. (179 aa)
	MEIS2	Homeoprotein Meis2a.2. (394 aa)
	ENO2	Gamma-enolase; Belongs to the enolase family. (434 aa)
	FGF10	Uncharacterized protein. (261 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (292 aa)
	HES6	Hes family bHLH transcription factor 6. (242 aa)
	MEIS1	Homeobox domain-containing protein. (465 aa)
	ROBO2	Roundabout guidance receptor 2. (1400 aa)
	FGF11	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL1	BMP4	ENSGALP00000047577	ENSGALP00000020289	BHLH domain-containing protein.	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	0.509
ASCL1	DLX5	ENSGALP00000047577	ENSGALP00000014846	BHLH domain-containing protein.	Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family.	0.483
ASCL1	FEZF2	ENSGALP00000047577	ENSGALP00000011620	BHLH domain-containing protein.	FEZ family zinc finger 2.	0.555
ASCL1	FGF10	ENSGALP00000047577	ENSGALP00000065453	BHLH domain-containing protein.	Uncharacterized protein.	0.406
ASCL1	FGF11	ENSGALP00000047577	ENSGALP00000073219	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.424
ASCL1	FGF12	ENSGALP00000047577	ENSGALP00000051076	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.410
ASCL1	FGF13	ENSGALP00000047577	ENSGALP00000054094	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.420
ASCL1	FGF14	ENSGALP00000047577	ENSGALP00000027195	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.408
ASCL1	FGF16	ENSGALP00000047577	ENSGALP00000012648	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.410
ASCL1	FGF18	ENSGALP00000047577	ENSGALP00000054695	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.433
ASCL1	FGF19	ENSGALP00000047577	ENSGALP00000043371	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.428
ASCL1	FGF20	ENSGALP00000047577	ENSGALP00000022184	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.422
ASCL1	FGF22	ENSGALP00000047577	ENSGALP00000046847	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.408
ASCL1	FGF23	ENSGALP00000047577	ENSGALP00000042002	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.408
ASCL1	FGF5	ENSGALP00000047577	ENSGALP00000065598	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.422
ASCL1	FGF6	ENSGALP00000047577	ENSGALP00000027889	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.408
ASCL1	FGF7	ENSGALP00000047577	ENSGALP00000042868	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.408
ASCL1	FGF8	ENSGALP00000047577	ENSGALP00000032574	BHLH domain-containing protein.	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family.	0.532
ASCL1	FGF9	ENSGALP00000047577	ENSGALP00000041598	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.422
ASCL1	FOXG1	ENSGALP00000047577	ENSGALP00000054672	BHLH domain-containing protein.	Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes.	0.650