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ANXA2P2 ANXA2P2 MTOR MTOR SAR1A SAR1A AMN AMN FSHB FSHB BANK1 BANK1 C3AR1 C3AR1 NTRK1 NTRK1 ING4 ING4 F2RL1 F2RL1 TXN TXN CYP17A1 CYP17A1 OVAL OVAL ZP2 ZP2 GALR1 GALR1 GAL GAL CCK CCK WNT4 WNT4 OVALY OVALY HGF HGF AMH AMH OVALX OVALX NCAM1 NCAM1 STMN2 STMN2 ACTB ACTB NRP1 NRP1 ACADL ACADL POMC POMC PLAG1 PLAG1 IL15 IL15 PIK3C3 PIK3C3 PRLR PRLR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ANXA2P2Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. (339 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
SAR1ASecretion associated Ras related GTPase 1A; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
AMNUncharacterized protein. (477 aa)
FSHBFollicle stimulating hormone, beta polypeptide. (131 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (730 aa)
C3AR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (461 aa)
NTRK1High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors that regulate distinct overlapping signali [...] (790 aa)
ING4Inhibitor of growth protein 4; Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (By similarity); Belongs to the ING family. (249 aa)
F2RL1G_PROTEIN_RECEP_F1_2 domain-containing protein. (391 aa)
TXNThioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (105 aa)
CYP17A1Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. (527 aa)
OVALOvalbumin; Non-inhibitory serpin. Storage protein of egg white. (386 aa)
ZP2ZP domain-containing protein. (829 aa)
GALR1Galanin receptor; Belongs to the G-protein coupled receptor 1 family. (357 aa)
GALGalanin variant 1. (141 aa)
CCKCholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes. (130 aa)
WNT4Protein Wnt-4; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development (By similarity). (351 aa)
OVALYOvalbumin-related protein Y; Belongs to the serpin family. Ov-serpin subfamily. (388 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (726 aa)
AMHTGF_BETA_2 domain-containing protein. (644 aa)
OVALXOvalbumin-related protein X; Belongs to the serpin family. Ov-serpin subfamily. (388 aa)
NCAM1Neural cell adhesion molecule 1; This protein is a cell adhesion molecule involved in neuron- neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. (1109 aa)
STMN2Stathmin-2; Is a key regulator of neurite extension through regulation of microtubule instabilily. (179 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
NRP1Neuropilin-1; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction (By similarity); Belongs t [...] (914 aa)
ACADLUncharacterized protein. (437 aa)
POMCUncharacterized protein. (251 aa)
PLAG1Zinc finger protein PLAG1; Transcription factor and proto-oncogene whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation. (501 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (187 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (944 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin; Belongs to the type I cytokine receptor family. Type 1 subfamily. (831 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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