node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDN3 | MC1R | ENSGALP00000056488 | ENSGALP00000071620 | Endothelin 3. | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family. | 0.752 |
EDN3 | PMEL | ENSGALP00000056488 | ENSGALP00000051268 | Endothelin 3. | Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family. | 0.519 |
EDN3 | TYR | ENSGALP00000056488 | ENSGALP00000027812 | Endothelin 3. | Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. | 0.717 |
FGF4 | MCAM | ENSGALP00000012214 | ENSGALP00000053585 | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb development during embryogenesis (By similarity). | Uncharacterized protein. | 0.462 |
MC1R | EDN3 | ENSGALP00000071620 | ENSGALP00000056488 | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family. | Endothelin 3. | 0.752 |
MC1R | PMEL | ENSGALP00000071620 | ENSGALP00000051268 | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family. | Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family. | 0.751 |
MC1R | SLC45A2 | ENSGALP00000071620 | ENSGALP00000005236 | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family. | Uncharacterized protein. | 0.861 |
MC1R | TYR | ENSGALP00000071620 | ENSGALP00000027812 | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family. | Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. | 0.919 |
MCAM | FGF4 | ENSGALP00000053585 | ENSGALP00000012214 | Uncharacterized protein. | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb development during embryogenesis (By similarity). | 0.462 |
MCAM | RNF26 | ENSGALP00000053585 | ENSGALP00000063912 | Uncharacterized protein. | Ring finger protein 26. | 0.701 |
MCAM | THY1 | ENSGALP00000053585 | ENSGALP00000040036 | Uncharacterized protein. | Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. | 0.456 |
MCAM | USP2 | ENSGALP00000053585 | ENSGALP00000063447 | Uncharacterized protein. | Ubiquitin carboxyl-terminal hydrolase 2; Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Possesses both ubiquitin- specific peptidase and isopeptidase activities. May play a role in the regulation of the circadian clock; Belongs to the peptidase C19 family. USP2 subfamily. | 0.481 |
NECTIN1 | RNF26 | ENSGALP00000057900 | ENSGALP00000063912 | Nectin cell adhesion molecule 1. | Ring finger protein 26. | 0.435 |
PMEL | EDN3 | ENSGALP00000051268 | ENSGALP00000056488 | Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family. | Endothelin 3. | 0.519 |
PMEL | MC1R | ENSGALP00000051268 | ENSGALP00000071620 | Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family. | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family. | 0.751 |
PMEL | SLC45A2 | ENSGALP00000051268 | ENSGALP00000005236 | Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family. | Uncharacterized protein. | 0.865 |
PMEL | TYR | ENSGALP00000051268 | ENSGALP00000027812 | Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family. | Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. | 0.957 |
RNF26 | MCAM | ENSGALP00000063912 | ENSGALP00000053585 | Ring finger protein 26. | Uncharacterized protein. | 0.701 |
RNF26 | NECTIN1 | ENSGALP00000063912 | ENSGALP00000057900 | Ring finger protein 26. | Nectin cell adhesion molecule 1. | 0.435 |
RNF26 | USP2 | ENSGALP00000063912 | ENSGALP00000063447 | Ring finger protein 26. | Ubiquitin carboxyl-terminal hydrolase 2; Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Possesses both ubiquitin- specific peptidase and isopeptidase activities. May play a role in the regulation of the circadian clock; Belongs to the peptidase C19 family. USP2 subfamily. | 0.426 |