STRINGSTRING
GDPD4 GDPD4 UTP18 UTP18 THSD4 THSD4 TIMM10 TIMM10 VMP1 VMP1 ACVR2B ACVR2B MRPL46 MRPL46 PAPPA PAPPA ITGA11 ITGA11 PACC1 PACC1 HMGA2 HMGA2 FAM13A FAM13A KIF26B KIF26B SNX10 SNX10 RAB5A RAB5A PRDM5 PRDM5 NDST4 NDST4 KIF5C KIF5C CMSS1 CMSS1 COQ3 COQ3 EPHA7 EPHA7 PRIM2 PRIM2 ZNF451 ZNF451 HMGCLL1 HMGCLL1 HBBR HBBR CDH6 CDH6 SLC43A3 SLC43A3 HBE1 HBE1 HBBA HBBA PHLPP1 PHLPP1 CCNC CCNC AGMO AGMO FARP1 FARP1 ARFIP2 ARFIP2 ADIPOR2 ADIPOR2 ADGRL3 ADGRL3 GPC5 GPC5 PABPC1 PABPC1 ADGRA3 ADGRA3 RELA RELA YPEL4 YPEL4 STAU2 STAU2 GABRB3 GABRB3 PPFIA2 PPFIA2 KIF23 KIF23 CACNB4 CACNB4 NCAPG NCAPG CBX3 CBX3 CDYL CDYL RTN4RL2 RTN4RL2 ITGB1 ITGB1 PUDP PUDP HNRNPA2B1 HNRNPA2B1 AGTR1 AGTR1 GTDC1 GTDC1 GABRG3 GABRG3 TOGARAM1 TOGARAM1 CBR4 CBR4 PGR2/3 PGR2/3 EPB41 EPB41 MDGA1 MDGA1 ETV3 ETV3 TRIM3 TRIM3 TENM3 TENM3 HTR2C HTR2C SMYD3 SMYD3 DRAP1 DRAP1 DCLK1 DCLK1 SLIT3 SLIT3 MANEA MANEA ZEB2 ZEB2 SEPTIN9 SEPTIN9 KAT5 KAT5 ATF3 ATF3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GDPD4Glycerophosphodiester phosphodiesterase domain containing 4. (580 aa)
UTP18UTP18 small subunit processome component. (607 aa)
THSD4Thrombospondin type 1 domain containing 4. (1026 aa)
TIMM10zf-Tim10_DDP domain-containing protein. (90 aa)
VMP1Vacuole membrane protein 1. (406 aa)
ACVR2BActivin receptor type-2B; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
MRPL46MRP-L46 domain-containing protein. (286 aa)
PAPPAPappalysin 1. (1670 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1240 aa)
PACC1Proton activated chloride channel 1. (356 aa)
HMGA2High mobility group protein I-C. (109 aa)
FAM13AFamily with sequence similarity 13 member A. (983 aa)
KIF26BKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2119 aa)
SNX10PX domain-containing protein. (201 aa)
RAB5AUncharacterized protein. (215 aa)
PRDM5PR/SET domain 5. (633 aa)
NDST4N-deacetylase and N-sulfotransferase 4. (873 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (957 aa)
CMSS1Uncharacterized protein. (267 aa)
COQ3Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (284 aa)
EPHA7Ephrin type-A receptor 7; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repel [...] (993 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (508 aa)
ZNF451Zinc finger protein 451. (1069 aa)
HMGCLL13-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (338 aa)
HBBRHemoglobin subunit rho; The rho chain is the major early embryonic beta-type hemoglobin chain. (147 aa)
CDH6Cadherin-6; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. (790 aa)
SLC43A3Solute carrier family 43 member 3. (706 aa)
HBE1Beta-H globin; Belongs to the globin family. (147 aa)
HBBAHemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. The beta chain is a component of adult hemoglobin A and D. (147 aa)
PHLPP1PH domain and leucine rich repeat protein phosphatase 1. (1552 aa)
CCNCCyclin-C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase CDK8 that phosphoryla [...] (283 aa)
AGMOAlkylglycerol monooxygenase; Belongs to the sterol desaturase family. (510 aa)
FARP1FERM, ARHGEF and pleckstrin domain-containing protein 1; Functions as guanine nucleotide exchange factor for RAC1 (By similarity). Plays a role in semaphorin signaling via its interaction with PLXNA4. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses. (1045 aa)
ARFIP2ADP ribosylation factor interacting protein 2. (394 aa)
ADIPOR2Uncharacterized protein. (386 aa)
ADGRL3Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. (1519 aa)
GPC5Glypican 5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (624 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (637 aa)
ADGRA3Adhesion G protein-coupled receptor A3; Belongs to the G-protein coupled receptor 2 family. (1122 aa)
RELATranscription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites tha [...] (559 aa)
YPEL4Protein yippee-like; Belongs to the yippee family. (108 aa)
STAU2Uncharacterized protein. (642 aa)
GABRB3Gamma-aminobutyric acid receptor subunit beta-3; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA- gated ion channel (By similarity). (476 aa)
PPFIA2PTPRF interacting protein alpha 2. (1283 aa)
KIF23Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (972 aa)
CACNB4SH3 domain-containing protein. (480 aa)
NCAPGNon-SMC condensin I complex subunit G. (1038 aa)
CBX3Uncharacterized protein. (184 aa)
CDYLChromo domain-containing protein. (871 aa)
RTN4RL2LRRCT domain-containing protein. (353 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (822 aa)
PUDPPseudouridine 5'-phosphatase. (235 aa)
HNRNPA2B1Uncharacterized protein. (374 aa)
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. (359 aa)
GTDC1Glycosyltransferase-like domain-containing protein 1; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. (464 aa)
GABRG3Gamma-aminobutyric acid type A receptor gamma3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
TOGARAM1TOG array regulator of axonemal microtubules 1. (1580 aa)
CBR4Carbonyl reductase 4. (247 aa)
PGR2/3C-type lectin domain-containing protein. (152 aa)
EPB41Erythroid protein 4.1; Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. May be required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase. (1239 aa)
MDGA1MAM domain-containing glycosylphosphatidylinositol anchor protein 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex. (1009 aa)
ETV3ETS variant 3. (532 aa)
TRIM3Tripartite motif containing 3. (862 aa)
TENM3Uncharacterized protein. (2807 aa)
HTR2C5-hydroxytryptamine (Serotonin) receptor 2C. (472 aa)
SMYD3SET and MYND domain containing 3. (487 aa)
DRAP1DR1 associated protein 1. (213 aa)
DCLK1Uncharacterized protein. (740 aa)
SLIT3Uncharacterized protein. (1641 aa)
MANEAMannosidase endo-alpha. (457 aa)
ZEB2Smad-interacting protein 1. (1214 aa)
SEPTIN9Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (615 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (302 aa)
ATF3Activating transcription factor 3. (181 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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