9 items (Gallus gallus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	FGF1	Endothelial cell growth factor alpha; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with [...] (155 aa)
	POMC	Uncharacterized protein. (251 aa)
	TH	Tyrosine hydroxylase. (491 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
	SST	Somatostatin-14; Somatostatin inhibits the release of somatotropin. (116 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
	STAT5A	Signal transducer and activator of transcription. (764 aa)
	AGRP	Agouti-related protein. (233 aa)
	GFAP	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (422 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGRP	INS	ENSGALP00000003505	ENSGALP00000010567	Agouti-related protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.860
AGRP	POMC	ENSGALP00000003505	ENSGALP00000063133	Agouti-related protein.	Uncharacterized protein.	0.985
AGRP	SST	ENSGALP00000003505	ENSGALP00000011889	Agouti-related protein.	Somatostatin-14; Somatostatin inhibits the release of somatotropin.	0.515
AGRP	TH	ENSGALP00000003505	ENSGALP00000051175	Agouti-related protein.	Tyrosine hydroxylase.	0.624
FGF1	FGF19	ENSGALP00000070539	ENSGALP00000043371	Endothelial cell growth factor alpha; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.649
FGF1	INS	ENSGALP00000070539	ENSGALP00000010567	Endothelial cell growth factor alpha; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with [...]	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.665
FGF19	FGF1	ENSGALP00000043371	ENSGALP00000070539	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Endothelial cell growth factor alpha; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with [...]	0.649
FGF19	GFAP	ENSGALP00000043371	ENSGALP00000001335	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.469
FGF19	INS	ENSGALP00000043371	ENSGALP00000010567	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.811
GFAP	FGF19	ENSGALP00000001335	ENSGALP00000043371	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.469
GFAP	INS	ENSGALP00000001335	ENSGALP00000010567	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.640
GFAP	POMC	ENSGALP00000001335	ENSGALP00000063133	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Uncharacterized protein.	0.435
GFAP	SST	ENSGALP00000001335	ENSGALP00000011889	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Somatostatin-14; Somatostatin inhibits the release of somatotropin.	0.592
GFAP	TH	ENSGALP00000001335	ENSGALP00000051175	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Tyrosine hydroxylase.	0.845
INS	AGRP	ENSGALP00000010567	ENSGALP00000003505	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Agouti-related protein.	0.860
INS	FGF1	ENSGALP00000010567	ENSGALP00000070539	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Endothelial cell growth factor alpha; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with [...]	0.665
INS	FGF19	ENSGALP00000010567	ENSGALP00000043371	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.811
INS	GFAP	ENSGALP00000010567	ENSGALP00000001335	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.640
INS	POMC	ENSGALP00000010567	ENSGALP00000063133	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.861
INS	SST	ENSGALP00000010567	ENSGALP00000011889	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Somatostatin-14; Somatostatin inhibits the release of somatotropin.	0.943