(25 nodes) (2021) Immunomodulatory effects of poly(I:C)-stimulated exosomes derived from chicken macrophages. network (Gallus gallus)

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second shell of interactors

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Predicted Interactions

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Your Input:
	CCL4	C-C motif chemokine 4 homolog. (89 aa)
	TRAF1	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
	TRAF4	TNF receptor-associated factor. (470 aa)
	CD40LG	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Belongs to the tumor necrosis factor family. (272 aa)
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
	EIF2AK2	Uncharacterized protein. (550 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
	IL17A	Uncharacterized protein. (169 aa)
	CD9	Tetraspanin. (224 aa)
	IRF7	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...] (491 aa)
	CD40	Uncharacterized protein. (299 aa)
	IL4	Interleukin 4. (136 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (299 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	CD8A-2	Ig-like domain-containing protein. (235 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
	CD4	Uncharacterized protein. (487 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	CCL4-2	C-C motif chemokine 4 homolog; Monokine with inflammatory and chemokinetic properties. (96 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (544 aa)
	IFNA3	Interferon. (193 aa)
	CD8A-3	Ig-like domain-containing protein. (318 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL4	CCL4-2	ENSGALP00000055424	ENSGALP00000067768	C-C motif chemokine 4 homolog.	C-C motif chemokine 4 homolog; Monokine with inflammatory and chemokinetic properties.	0.903
CCL4	CD4	ENSGALP00000055424	ENSGALP00000065611	C-C motif chemokine 4 homolog.	Uncharacterized protein.	0.721
CCL4	CD40	ENSGALP00000055424	ENSGALP00000038316	C-C motif chemokine 4 homolog.	Uncharacterized protein.	0.487
CCL4	CD8A-2	ENSGALP00000055424	ENSGALP00000059832	C-C motif chemokine 4 homolog.	Ig-like domain-containing protein.	0.709
CCL4	CD8A-3	ENSGALP00000055424	ENSGALP00000071819	C-C motif chemokine 4 homolog.	Ig-like domain-containing protein.	0.709
CCL4	GAPDH	ENSGALP00000055424	ENSGALP00000063325	C-C motif chemokine 4 homolog.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	0.408
CCL4	IFNA3	ENSGALP00000055424	ENSGALP00000070204	C-C motif chemokine 4 homolog.	Interferon.	0.601
CCL4	IL17A	ENSGALP00000055424	ENSGALP00000026862	C-C motif chemokine 4 homolog.	Uncharacterized protein.	0.669
CCL4	IL1B	ENSGALP00000055424	ENSGALP00000050171	C-C motif chemokine 4 homolog.	Interleukin-1; Belongs to the IL-1 family.	0.796
CCL4	IL4	ENSGALP00000055424	ENSGALP00000039130	C-C motif chemokine 4 homolog.	Interleukin 4.	0.625
CCL4	IL6	ENSGALP00000055424	ENSGALP00000068117	C-C motif chemokine 4 homolog.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.841
CCL4	IRF7	ENSGALP00000055424	ENSGALP00000038233	C-C motif chemokine 4 homolog.	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...]	0.533
CCL4	MYD88	ENSGALP00000055424	ENSGALP00000042597	C-C motif chemokine 4 homolog.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.499
CCL4	TLR3	ENSGALP00000055424	ENSGALP00000021914	C-C motif chemokine 4 homolog.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.535
CCL4	TLR4	ENSGALP00000055424	ENSGALP00000011319	C-C motif chemokine 4 homolog.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.536
CCL4-2	CCL4	ENSGALP00000067768	ENSGALP00000055424	C-C motif chemokine 4 homolog; Monokine with inflammatory and chemokinetic properties.	C-C motif chemokine 4 homolog.	0.903
CCL4-2	CD4	ENSGALP00000067768	ENSGALP00000065611	C-C motif chemokine 4 homolog; Monokine with inflammatory and chemokinetic properties.	Uncharacterized protein.	0.780
CCL4-2	CD40	ENSGALP00000067768	ENSGALP00000038316	C-C motif chemokine 4 homolog; Monokine with inflammatory and chemokinetic properties.	Uncharacterized protein.	0.632
CCL4-2	CD40LG	ENSGALP00000067768	ENSGALP00000010340	C-C motif chemokine 4 homolog; Monokine with inflammatory and chemokinetic properties.	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Belongs to the tumor necrosis factor family.	0.544
CCL4-2	CD8A-2	ENSGALP00000067768	ENSGALP00000059832	C-C motif chemokine 4 homolog; Monokine with inflammatory and chemokinetic properties.	Ig-like domain-containing protein.	0.770