STRINGSTRING
ERCC8 ERCC8 CDC45 CDC45 SIN3A SIN3A WDR5B WDR5B BRCA1 BRCA1 MLXIP MLXIP RAD18 RAD18 CDK6 CDK6 MDM2 MDM2 RPL37A RPL37A ZRANB3 ZRANB3 BCL2 BCL2 CDT1 CDT1 CDK7 CDK7 ATM ATM YY2 YY2 H3F3C H3F3C RAD50 RAD50 MYCL MYCL WEE1 WEE1 PPP2R2A PPP2R2A UVSSA UVSSA XRCC6 XRCC6 RAD21 RAD21 USP7 USP7 SMAD2Z SMAD2Z ZRANB3-2 ZRANB3-2 MCM10 MCM10 PRKDC PRKDC PCNA PCNA MYCN MYCN CDK18 CDK18 CDC6 CDC6 WRN WRN LMNA-2 LMNA-2 INO80C INO80C MYC MYC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (399 aa)
CDC45Cell division cycle 45. (566 aa)
SIN3AHDAC_interact domain-containing protein. (1274 aa)
WDR5BWD_REPEATS_REGION domain-containing protein. (334 aa)
BRCA1Uncharacterized protein. (1749 aa)
MLXIPMLX interacting protein. (881 aa)
RAD18Uncharacterized protein. (672 aa)
CDK6Cyclin-dependent kinase; Belongs to the protein kinase superfamily. (326 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (483 aa)
RPL37AUncharacterized protein; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (966 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (420 aa)
BCL2Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
CDT1Chromatin licensing and DNA replication factor 1. (745 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
ATMNon-specific serine/threonine protein kinase. (3050 aa)
YY2Uncharacterized protein. (420 aa)
H3F3CHistone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
RAD50Zinc-hook domain-containing protein. (1313 aa)
MYCLMYCL proto-oncogene, bHLH transcription factor. (347 aa)
WEE1Wee1-like protein kinase. (641 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (494 aa)
UVSSAUV-stimulated scaffold protein A; Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (By similarity); Belongs to the UVSSA family. (739 aa)
XRCC6X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...] (647 aa)
RAD21Uncharacterized protein. (633 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins, such as p53/TP53. Deubiquitinates p53/TP53, and thereby modulates p53/TP53 stability, p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. May be involved in cell proliferation during early embryonic development (By similarity). (1102 aa)
SMAD2ZMothers against decapentaplegic homolog. (467 aa)
ZRANB3-2HNH domain-containing protein. (442 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (705 aa)
PRKDCDNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act a [...] (4132 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
MYCNN-myc proto-oncogene protein. (441 aa)
CDK18Cyclin dependent kinase 18. (615 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (554 aa)
WRNUncharacterized protein. (1622 aa)
LMNA-2Lamin-B2; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin; Belongs to the intermediate filament family. (658 aa)
INO80CINO80 complex subunit C. (185 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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