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NFIB | Nuclear factor 1 B-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (560 aa) | ||||
SLC1A3 | Amino acid transporter. (543 aa) | ||||
PAX6 | Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development. (500 aa) | ||||
TXLNB | Beta-taxilin; Promotes neurite-outgrowth. May be involved in intracellular vesicle traffic. (693 aa) | ||||
NEUROD6 | Neurogenic differentiation factor. (337 aa) | ||||
CDHR3 | Uncharacterized protein. (174 aa) | ||||
PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound he [...] (1106 aa) | ||||
FABP7 | Fatty acid-binding protein, brain; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa) | ||||
TBX2 | T-box transcription factor 2. (693 aa) | ||||
NEUROG1 | Neurogenin 1. (179 aa) | ||||
PAX3 | Paired-box transcription factor protein PAX3. (484 aa) | ||||
NKX6-1 | NK6 homeobox 1. (272 aa) | ||||
MNX1 | Homeobox domain-containing protein. (348 aa) | ||||
STMN2 | Stathmin-2; Is a key regulator of neurite extension through regulation of microtubule instabilily. (179 aa) | ||||
NKX2-2 | Homeobox domain-containing protein. (272 aa) | ||||
TBX20 | T-box transcription factor TBX20; Acts as a transcriptional regulator involved in heart developmental processes. (440 aa) | ||||
TUBB3 | Tubulin beta-4 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (496 aa) | ||||
DHRS4 | Uncharacterized protein. (273 aa) | ||||
NEUROD2 | Neurogenic differentiation factor. (356 aa) | ||||
NFIA | Nuclear factor 1 A-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (582 aa) | ||||
RRAD | Uncharacterized protein. (303 aa) | ||||
GLI1 | Zinc finger protein GLI1; Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3' (By similarity). May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling. Belongs to the GLI C2H2-type zinc-finger protein family. (1281 aa) | ||||
OLIG2 | Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord. (298 aa) | ||||
SIX1 | Sine oculis-related homeobox 1 homolog. (282 aa) | ||||
SOX2 | Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa) | ||||
TBX3 | T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. (732 aa) | ||||
FGFR3 | Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] (806 aa) | ||||
ALB | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. (565 aa) | ||||
PAX7 | PAX7 protein. (524 aa) | ||||
ISL1 | Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa) | ||||
ARHGAP11B | Rho-GAP domain-containing protein. (996 aa) | ||||
PIFO | Primary cilia formation. (198 aa) | ||||
SOX9 | Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa) | ||||
HOPX | Homeodomain-only protein; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. May act via an interaction with SRF, leading to modulate the expression of SRF- dependent cardiac-specific genes and cardiac development. May act as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assist in chaperone-mediated protein refolding. (73 aa) | ||||
PHOX2B | Paired like homeobox 2B. (292 aa) | ||||
S100B | EF-hand domain-containing protein; Belongs to the S-100 family. (92 aa) | ||||
CDH7 | Cadherin-7; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. (785 aa) | ||||
SOX10 | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. (461 aa) | ||||
NKX6-2 | Homeobox domain-containing protein. (364 aa) | ||||
CBWD1 | CobW C-terminal domain-containing protein. (370 aa) | ||||
NEUROD1 | Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa) | ||||
SHH | Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa) |