STRINGSTRING
PENK PENK IL10 IL10 CCL20 CCL20 MTOR MTOR GDNF GDNF RAMP1 RAMP1 LOC100859347 LOC100859347 TRPV1 TRPV1 CSF1R CSF1R INS INS VIPR2 VIPR2 TLR4 TLR4 IL18 IL18 GHRL GHRL NMUR1 NMUR1 ARG2 ARG2 IL22 IL22 NPY NPY JAK1 JAK1 HIF1A HIF1A MC4R MC4R LOC418170 LOC418170 NTRK1 NTRK1 TLR3 TLR3 IL17A IL17A ADRB3 ADRB3 NMU NMU GCG GCG OVAL OVAL SLC2A14 SLC2A14 IL4 IL4 GAL GAL FOXP1 FOXP1 AHR AHR CCR7 CCR7 ADRB2 ADRB2 IL1B IL1B IL4R IL4R CALB1 CALB1 RAG1 RAG1 NOS1 NOS1 CD8A-2 CD8A-2 POMC POMC CSF1 CSF1 CD4 CD4 CALCRL CALCRL IL6 IL6 CD36 CD36 GATA3 GATA3 IL17RA IL17RA IFNA3 IFNA3 CD8A-3 CD8A-3 PIK3C3 PIK3C3 NOS3 NOS3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PENKProenkephalin. (267 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
CCL20C-C motif chemokine. (100 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
GDNFGlial cell derived neurotrophic factor. (209 aa)
RAMP1Receptor activity modifying protein 1. (125 aa)
LOC100859347Uncharacterized protein. (964 aa)
TRPV1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (843 aa)
CSF1RUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
VIPR2VPAC2 receptor; Belongs to the G-protein coupled receptor 2 family. (439 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
IL18Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. (198 aa)
GHRLPreproghrelin. (116 aa)
NMUR1Neuromedin U receptor type 1; Belongs to the G-protein coupled receptor 1 family. (438 aa)
ARG2Arginase. (356 aa)
IL22Uncharacterized protein. (197 aa)
NPYC-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa)
JAK1Tyrosine-protein kinase. (1150 aa)
HIF1AHypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators (By similarity). (811 aa)
MC4RG_PROTEIN_RECEP_F1_2 domain-containing protein. (331 aa)
LOC418170Aldo_ket_red domain-containing protein. (314 aa)
NTRK1High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors that regulate distinct overlapping signali [...] (790 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
IL17AUncharacterized protein. (169 aa)
ADRB3G_PROTEIN_RECEP_F1_2 domain-containing protein. (425 aa)
NMUNeuromedin-U-25; Stimulates uterine smooth muscle contraction and causes selective vasoconstriction; Belongs to the NmU family. (181 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. (206 aa)
OVALOvalbumin; Non-inhibitory serpin. Storage protein of egg white. (386 aa)
SLC2A14Solute carrier family 2, facilitated glucose transporter member 3; Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. (496 aa)
IL4Interleukin 4. (136 aa)
GALGalanin variant 1. (141 aa)
FOXP1Forkhead box protein P1; Transcriptional repressor. (686 aa)
AHRUncharacterized protein. (877 aa)
CCR7C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
ADRB2Adrenoceptor beta 2. (402 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
IL4RFibronectin type-III domain-containing protein. (996 aa)
CALB1Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. (262 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break b [...] (1041 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1435 aa)
CD8A-2Ig-like domain-containing protein. (235 aa)
POMCUncharacterized protein. (251 aa)
CSF1Uncharacterized protein. (493 aa)
CD4Uncharacterized protein. (487 aa)
CALCRLCalcitonin receptor-like receptor; Belongs to the G-protein coupled receptor 2 family. (457 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
CD36Uncharacterized protein; Belongs to the CD36 family. (471 aa)
GATA3GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa)
IL17RASEFIR domain-containing protein. (978 aa)
IFNA3Interferon. (193 aa)
CD8A-3Ig-like domain-containing protein. (318 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (944 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1402 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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