STRINGSTRING
MAVS MAVS CHUK CHUK STAT2 STAT2 STAT4 STAT4 USP7 USP7 USP47 USP47 NFKBIA NFKBIA IRF7 IRF7 CGAS CGAS USP14 USP14 RBX1 RBX1 EIF2AK2 EIF2AK2 MDM2 MDM2 CYLD CYLD IFNG IFNG STAT5A STAT5A PLP1 PLP1 TTC1 TTC1 CD4 CD4 TRAF3 TRAF3 TRAF6 TRAF6 CUL5 CUL5 MYC MYC IFNA3 IFNA3 STAT1 STAT1 IFIH1 IFIH1 NFX1 NFX1 USP15 USP15 CUL2 CUL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAVSCARD_2 domain-containing protein. (641 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (724 aa)
STAT2Signal transducer and activator of transcription. (961 aa)
STAT4Signal transducer and activator of transcription. (749 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins, such as p53/TP53. Deubiquitinates p53/TP53, and thereby modulates p53/TP53 stability, p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. May be involved in cell proliferation during early embryonic development (By similarity). (1102 aa)
USP47Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). (1376 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity). (318 aa)
IRF7Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...] (491 aa)
CGASCyclic GMP-AMP synthase. (294 aa)
USP14Ubiquitin carboxyl-terminal hydrolase. (466 aa)
RBX1RING-type domain-containing protein. (108 aa)
EIF2AK2Uncharacterized protein. (550 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (483 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (941 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (164 aa)
STAT5ASignal transducer and activator of transcription. (764 aa)
PLP1Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin; Belongs to the myelin proteolipid protein family. (277 aa)
TTC1Tetratricopeptide repeat domain 1. (296 aa)
CD4Uncharacterized protein. (487 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
CUL5Cullin 5; Belongs to the cullin family. (662 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa)
IFNA3Interferon. (193 aa)
STAT1Signal transducer and activator of transcription. (755 aa)
IFIH1Uncharacterized protein. (1102 aa)
NFX1Nuclear transcription factor, X-box binding 1. (1134 aa)
USP15Ubiquitin carboxyl-terminal hydrolase. (981 aa)
CUL2CULLIN_2 domain-containing protein; Belongs to the cullin family. (774 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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