(24 nodes) (2021) Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review. network (Gallus gallus)

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second shell of interactors

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	PRODH	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (602 aa)
	PRODH2	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (161 aa)
	TJP2	Uncharacterized protein; Belongs to the MAGUK family. (1373 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (1771 aa)
	CLDN1	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	ASS1	Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues; Belongs to the argininosuccinate synthase family. (416 aa)
	HMOX1	Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. (317 aa)
	LPO	Uncharacterized protein. (790 aa)
	COMT	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (262 aa)
	ENSGALP00000070065	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (154 aa)
	MMP9	Uncharacterized protein. (713 aa)
	ASL2	Argininosuccinate lyase; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. (572 aa)
	TNFRSF1B	Uncharacterized protein. (462 aa)
	PRDX3	Peroxiredoxin 3. (309 aa)
	OAT	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
	LRTOMT	Uncharacterized protein. (259 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	IL17A	Uncharacterized protein. (169 aa)
	ARG2	Arginase. (356 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (164 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
	TXN	Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (105 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
	STAT3	Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARG2	ASL2	ENSGALP00000015485	ENSGALP00000058708	Arginase.	Argininosuccinate lyase; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	0.971
ARG2	ASS1	ENSGALP00000015485	ENSGALP00000038774	Arginase.	Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues; Belongs to the argininosuccinate synthase family.	0.800
ARG2	ENSGALP00000070065	ENSGALP00000015485	ENSGALP00000070065	Arginase.	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.	0.624
ARG2	IFNG	ENSGALP00000015485	ENSGALP00000016086	Arginase.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.507
ARG2	IL10	ENSGALP00000015485	ENSGALP00000001310	Arginase.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.787
ARG2	IL1B	ENSGALP00000015485	ENSGALP00000050171	Arginase.	Interleukin-1; Belongs to the IL-1 family.	0.593
ARG2	OAT	ENSGALP00000015485	ENSGALP00000053373	Arginase.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.999
ARG2	PRODH	ENSGALP00000015485	ENSGALP00000012517	Arginase.	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.	0.575
ARG2	PRODH2	ENSGALP00000015485	ENSGALP00000049921	Arginase.	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.	0.593
ARG2	SOD2	ENSGALP00000015485	ENSGALP00000019039	Arginase.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.420
ARG2	STAT3	ENSGALP00000015485	ENSGALP00000005161	Arginase.	Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes.	0.432
ASL2	ARG2	ENSGALP00000058708	ENSGALP00000015485	Argininosuccinate lyase; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	Arginase.	0.971
ASL2	ASS1	ENSGALP00000058708	ENSGALP00000038774	Argininosuccinate lyase; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues; Belongs to the argininosuccinate synthase family.	0.999
ASL2	ENSGALP00000070065	ENSGALP00000058708	ENSGALP00000070065	Argininosuccinate lyase; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.	0.580
ASL2	OAT	ENSGALP00000058708	ENSGALP00000053373	Argininosuccinate lyase; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.986
ASL2	PRODH	ENSGALP00000058708	ENSGALP00000012517	Argininosuccinate lyase; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.	0.487
ASL2	PRODH2	ENSGALP00000058708	ENSGALP00000049921	Argininosuccinate lyase; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.	0.506
ASS1	ARG2	ENSGALP00000038774	ENSGALP00000015485	Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues; Belongs to the argininosuccinate synthase family.	Arginase.	0.800
ASS1	ASL2	ENSGALP00000038774	ENSGALP00000058708	Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues; Belongs to the argininosuccinate synthase family.	Argininosuccinate lyase; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	0.999
ASS1	ENSGALP00000070065	ENSGALP00000038774	ENSGALP00000070065	Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues; Belongs to the argininosuccinate synthase family.	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.	0.571