STRINGSTRING
EAAT5L EAAT5L RECQL5 RECQL5 BRCA1 BRCA1 BARD1 BARD1 FANCD2 FANCD2 NEDD4 NEDD4 UBE2I UBE2I CBL CBL SUMO2 SUMO2 SLC1A6 SLC1A6 RAD18 RAD18 UBR1 UBR1 CYLD CYLD MDM2 MDM2 SLC1A1 SLC1A1 RBX1 RBX1 SHPRH SHPRH USP41 USP41 CUL4A CUL4A ATM ATM H3F3C H3F3C UFD1L UFD1L HIST1H3H HIST1H3H FKBP1A FKBP1A CENPA CENPA RNF8 RNF8 SP3 SP3 PINK1 PINK1 SLC1A7 SLC1A7 COPS8 COPS8 HIST1H4B HIST1H4B EEA1 EEA1 TRIM28 TRIM28 CACUL1 CACUL1 SMAD2Z SMAD2Z NEDD8 NEDD8 ENSGALP00000055994 ENSGALP00000055994 SLC1A2 SLC1A2 HDAC1 HDAC1 PCNA PCNA REV1 REV1 SUMO1 SUMO1 ENSGALP00000069661 ENSGALP00000069661 SSRP1 SSRP1 SLC1A3 SLC1A3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EAAT5LAmino acid transporter. (586 aa)
RECQL5Uncharacterized protein. (1052 aa)
BRCA1Uncharacterized protein. (1749 aa)
BARD1Uncharacterized protein. (795 aa)
FANCD2Uncharacterized protein. (1510 aa)
NEDD4E3 ubiquitin-protein ligase. (932 aa)
UBE2ISUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
CBLUncharacterized protein. (903 aa)
SUMO2Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are al [...] (95 aa)
SLC1A6Amino acid transporter. (546 aa)
RAD18Uncharacterized protein. (672 aa)
UBR1E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1809 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (941 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (483 aa)
SLC1A1Amino acid transporter. (527 aa)
RBX1RING-type domain-containing protein. (108 aa)
SHPRHSNF2 histone linker PHD RING helicase. (1691 aa)
USP41Ubiquitin carboxyl-terminal hydrolase. (424 aa)
CUL4ACullin 4A; Belongs to the cullin family. (767 aa)
ATMNon-specific serine/threonine protein kinase. (3050 aa)
H3F3CHistone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
UFD1LUbiquitin fusion-degradation 1-like protein. (307 aa)
HIST1H3HHistone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
FKBP1APeptidylprolyl isomerase. (108 aa)
CENPAHistone H3-like centromeric protein A; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well- ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By simil [...] (131 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (529 aa)
SP3Transcription factor Sp3; Transcriptional factor that can act as an activator or repressor depending on post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription (By similarity). Required for activation of SPARC transcription; Belongs to the Sp1 C2H2-type zinc-finger protein family. (771 aa)
PINK1PTEN induced kinase 1. (364 aa)
SLC1A7Amino acid transporter. (560 aa)
COPS8PCI domain-containing protein. (230 aa)
HIST1H4BHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
EEA1Early endosome antigen 1. (1450 aa)
TRIM28Tripartite motif containing 28. (828 aa)
CACUL1Cullin domain-containing protein; Belongs to the cullin family. (377 aa)
SMAD2ZMothers against decapentaplegic homolog. (467 aa)
NEDD8NEDD8 ubiquitin like modifier. (85 aa)
ENSGALP00000055994Histone H3; Belongs to the histone H3 family. (136 aa)
SLC1A2Amino acid transporter. (554 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. (480 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (By similarity). May play a role in homologous recombination and immunoglobulin gene conversion; Belongs to the DNA polymerase type-Y family. (1276 aa)
SUMO1Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as [...] (135 aa)
ENSGALP00000069661Histone H3; Belongs to the histone H3 family. (98 aa)
SSRP1FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (706 aa)
SLC1A3Amino acid transporter. (543 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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