(17 nodes) (2022) Galectin network in osteoarthritis: galectin-4 programs a pathogenic signature of gene and effector expression in human chondrocytes in vitro. network (Gallus gallus)

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Your Input:
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
	ACAN	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2089 aa)
	CASP8	Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
	SDHA	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (665 aa)
	TAL1	T-cell acute lymphocytic leukemia protein 1 homolog; Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. (396 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
	CD4	Uncharacterized protein. (487 aa)
	CASP18	Initiator caspase; Belongs to the peptidase C14A family. (464 aa)
	COL1A1	Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1453 aa)
	LGALS3	Galectin. (258 aa)
	COL2A1	Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. (1420 aa)
	COL3A1	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	PXDNL	Uncharacterized protein. (1406 aa)
	ADAMTS4	ADAM metallopeptidase with thrombospondin type 1 motif 4. (644 aa)
	MMP3	ZnMc domain-containing protein. (477 aa)
	PXDN	Peroxidasin. (1611 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAN	ADAMTS4	ENSGALP00000010867	ENSGALP00000047303	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	ADAM metallopeptidase with thrombospondin type 1 motif 4.	0.919
ACAN	COL1A1	ENSGALP00000010867	ENSGALP00000058148	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen).	0.710
ACAN	COL2A1	ENSGALP00000010867	ENSGALP00000052906	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.	0.952
ACAN	COL3A1	ENSGALP00000010867	ENSGALP00000051057	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	0.990
ACAN	IL1B	ENSGALP00000010867	ENSGALP00000050171	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Interleukin-1; Belongs to the IL-1 family.	0.699
ACAN	IL6	ENSGALP00000010867	ENSGALP00000068117	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.549
ACAN	INS	ENSGALP00000010867	ENSGALP00000010567	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.559
ACAN	LGALS3	ENSGALP00000010867	ENSGALP00000055146	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Galectin.	0.486
ACAN	MMP3	ENSGALP00000010867	ENSGALP00000041145	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	ZnMc domain-containing protein.	0.752
ACAN	PXDN	ENSGALP00000010867	ENSGALP00000026363	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Peroxidasin.	0.449
ACAN	PXDNL	ENSGALP00000010867	ENSGALP00000049777	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Uncharacterized protein.	0.450
ADAMTS4	ACAN	ENSGALP00000047303	ENSGALP00000010867	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	0.919
ADAMTS4	COL2A1	ENSGALP00000047303	ENSGALP00000052906	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.	0.488
ADAMTS4	COL3A1	ENSGALP00000047303	ENSGALP00000051057	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	0.606
ADAMTS4	IL1B	ENSGALP00000047303	ENSGALP00000050171	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Interleukin-1; Belongs to the IL-1 family.	0.596
ADAMTS4	IL6	ENSGALP00000047303	ENSGALP00000068117	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.510
ADAMTS4	MMP3	ENSGALP00000047303	ENSGALP00000041145	ADAM metallopeptidase with thrombospondin type 1 motif 4.	ZnMc domain-containing protein.	0.788
CASP18	CASP8	ENSGALP00000065273	ENSGALP00000013591	Initiator caspase; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.915
CASP18	CD4	ENSGALP00000065273	ENSGALP00000065611	Initiator caspase; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.527
CASP18	IL1B	ENSGALP00000065273	ENSGALP00000050171	Initiator caspase; Belongs to the peptidase C14A family.	Interleukin-1; Belongs to the IL-1 family.	0.850