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| | FSHB | Follicle stimulating hormone, beta polypeptide. (131 aa) |
| | LHX2 | LIM homeodomain. (400 aa) |
| | STRA6 | Uncharacterized protein. (671 aa) |
| | LMX1A | Uncharacterized protein. (380 aa) |
| | WNT9A | Protein Wnt-9a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a role in embryonic chondrocyte maturation and in embryonic bone mineralization (By similarity). (503 aa) |
| | LHX1 | LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2. (406 aa) |
| | DKK3 | Dickkopf-related protein 3; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). (350 aa) |
| | SOX6 | HMG box domain-containing protein. (817 aa) |
| | SHH | Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa) |
| | CCND1 | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). (292 aa) |
| | BMP7 | Bone morphogenetic protein 7. (465 aa) |
| | TBX5 | T-box transcription factor TBX5; DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. May bind to the core DNA motif of promoters. (521 aa) |
| | WDPCP | WD repeat containing planar cell polarity effector. (807 aa) |
| | GPR50 | Melatonin receptor type 1C; High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity). (346 aa) |
| | VAX1 | Ventral anterior homeobox 1; Transcription factor that plays a role in establishing dorsal-ventral polarity in the neural retina. (325 aa) |
| | THRB | Thyroid hormone receptor beta; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine; Belongs to the nuclear hormone receptor family. NR1 subfamily. (476 aa) |
| | HIF1A | Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators (By similarity). (811 aa) |
| | BMP4 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. (404 aa) |
| | JARID2 | Protein Jumonji; Regulator of histone methyltransferase complexes that plays an essential role in embryonic development. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone [...] (1235 aa) |
| | ALDH1A1 | Retinal dehydrogenase 1; Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (By similarity). (509 aa) |
| | CYP26B1 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa) |
| | FGF2 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. (158 aa) |
| | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. (527 aa) |
| | FGF8 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa) |
| | NR2F1 | Nuclear receptor subfamily 2 group F member 1. (418 aa) |
| | SIX6 | Homeobox protein SIX6; May be involved in eye development. Belongs to the SIX/Sine oculis homeobox family. (447 aa) |
| | RARB | Retinoic acid receptor beta; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for limb and craniofacial development. (455 aa) |
| | SOX9 | Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa) |
| | HDC | Uncharacterized protein. (664 aa) |
| | LAMC1 | Laminin subunit gamma 1. (1603 aa) |
| | RPL27 | 60S ribosomal protein L27; Belongs to the eukaryotic ribosomal protein eL27 family. (216 aa) |
| | WNT8B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa) |
| | THY1 | Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. (161 aa) |
| | HOXA3 | Homeobox protein Hox-A3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (413 aa) |
| | FGF3 | Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (220 aa) |
| | HOXB2 | Homeobox B2. (323 aa) |
| | ISL1 | Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa) |
| | HOXA13 | Homeobox protein Hox-A13; Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (305 aa) |
| | OTX5 | Orthodenticle-related homeobox 5. (287 aa) |
| | CDON | Cell adhesion associated, oncogene regulated. (1117 aa) |
| | WNT2B | Protein Wnt-2b; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Acts as an upstream regulator of FGF10 in the lateral plate mesoderm during limb initiation in the embryo. (385 aa) |
| | TBX3 | T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. (732 aa) |
| | SEMA3F | Sema domain-containing protein; Belongs to the semaphorin family. (838 aa) |
| | PAX2 | Paired-box containing protein Pax-2. (394 aa) |
| | SOX2 | Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa) |
| | PITX2 | Pituitary homeobox 2; May play an important role in development and maintenance of anterior structures. May play a role in determining left-right asymmetry and in vasculogenesis during avian embryogenesis. (333 aa) |
| | CBLN1 | Cerebellin 1 precursor. (194 aa) |
| | EFEMP1 | EGF containing fibulin extracellular matrix protein 1. (451 aa) |
| | TFEC | Transcription factor EC; Transcriptional regulator that acts as a repressor or an activator. Binds DNA (By similarity); Belongs to the MiT/TFE family. (440 aa) |
| | ASCL1 | BHLH domain-containing protein. (219 aa) |
| | HOXC4 | Homeobox C4. (379 aa) |
| | POU3F4 | POU domain protein. (247 aa) |
| | VSX2 | Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity); Belongs to the paired homeobox family. (377 aa) |
| | SHISA2 | Uncharacterized protein. (284 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (536 aa) |
| | HOXB5 | Homeobox protein Hox-B5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (264 aa) |
| | SMO | Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa) |
| | GSX2 | GS homeobox 2. (263 aa) |
| | SOX1 | Transcription factor SOX-1; Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural protein and suppresses neuronal differentiation. (373 aa) |
| | SOX4 | Transcription factor SOX. (428 aa) |
| | FOXA1 | Forkhead box A1. (442 aa) |
| | HOXB8 | Homeobox protein Hox-B8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (241 aa) |
| | FGF12 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa) |
| | HHLA1 | HERV-H LTR-associating 1. (445 aa) |
| | COL2A1 | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. (1420 aa) |
| | LMX1B | LIM/homeobox protein LMX-1.2; Specifies dorsal cell fate during limb development. (400 aa) |
| | RPL30 | 60S ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family. (115 aa) |
| | FOXG1 | Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. (451 aa) |
| | AXIN2 | Uncharacterized protein. (837 aa) |
| | NKX2-2 | Homeobox domain-containing protein. (272 aa) |
| | NKX2-1 | Homeobox domain-containing protein. (345 aa) |
| | ALDH1A3 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (512 aa) |
| | VSX1 | Visual system homeobox 1; Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster. May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (By similarity). Dispensable in early retinal development (By similarity). Belongs to the paired homeobox family. (349 aa) |
| | IRX1 | Homeobox domain-containing protein. (467 aa) |
| | LIN28A | Protein lin-28 homolog A; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization [...] (202 aa) |
| | OPTC | LRRNT domain-containing protein. (338 aa) |
| | WNT3A | Protein Wnt-3a; [Isoform 1]: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Regulates chick apical ectodermal ridge formation. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). ECO:0000250|UniProtKB:P56704. (376 aa) |
| | TBX2 | T-box transcription factor 2. (693 aa) |
| | SIX3 | Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] (314 aa) |
| | MEIS2 | Homeoprotein Meis2a.2. (394 aa) |
| | POU4F2 | POU domain protein. (418 aa) |
| | HOXB6 | Homeobox protein Hox-B6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (222 aa) |
| | HESX1 | Homeobox protein ANF-1; May be involved in the early patterning of the most anterior region of the main embryonic body axis. (210 aa) |
| | ATOH7 | Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. During retinal neurogenesis, activates its own transcription, as well as the transcription of CHRNB3 and BRN3. (151 aa) |
| | IRX2 | Homeobox domain-containing protein. (536 aa) |
| | EMX2 | Empty spiracles homeobox 2. (336 aa) |
| | CASP3 | Caspase-3; Belongs to the peptidase C14A family. (283 aa) |
| | RBPJ | Recombination signal binding protein for immunoglobulin kappa J region. (484 aa) |
| | PAX6 | Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development. (500 aa) |
| | FGF1 | Endothelial cell growth factor alpha; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with [...] (155 aa) |
| | PODXL | Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro- adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubul [...] (589 aa) |
| | OTX1 | Orthodenticle homeobox 1. (335 aa) |
