STRINGSTRING
HPGDS HPGDS STX17 STX17 OTX1 OTX1 MC1R MC1R MPDZ MPDZ POMC POMC GSC GSC CLCN7 CLCN7 LURAP1L LURAP1L PTPRD PTPRD KIT KIT FOXF2 FOXF2 MYO5A MYO5A LYST LYST ARX ARX NFIB NFIB MAFA MAFA BCO2 BCO2 TYRP1 TYRP1 EDNRB EDNRB MLANA MLANA TYR TYR OCA2 OCA2 SOX10 SOX10 SLC38A11 SLC38A11 SLC24A4 SLC24A4 TRPM1 TRPM1 SYP SYP SLC45A2 SLC45A2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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HPGDSHematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide. (199 aa)
STX17t-SNARE coiled-coil homology domain-containing protein. (302 aa)
OTX1Orthodenticle homeobox 1. (335 aa)
MC1RMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family. (314 aa)
MPDZUncharacterized protein. (2106 aa)
POMCUncharacterized protein. (251 aa)
GSCHomeobox protein goosecoid; Involved in the development of the organizer region in the gastrula (Hensen node in chicken). (346 aa)
CLCN7Chloride channel protein. (802 aa)
LURAP1LLeucine rich adaptor protein 1 like. (197 aa)
PTPRDProtein tyrosine phosphatase receptor type D. (1963 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...] (960 aa)
FOXF2Forkhead box F2. (389 aa)
MYO5AUnconventional myosin-Va; Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation (By similarity). (1830 aa)
LYSTUncharacterized protein. (1401 aa)
ARXAristaless related homeobox. (513 aa)
NFIBNuclear factor 1 B-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (560 aa)
MAFATranscription factor MafA; Transcription factor involved in transcription regulation during lens development, including that of crystallin and filensin/BFSP1 genes. Binds to CRE-type MARE 5'- TGCTGACGTCAGCA-3' and TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequences ; Belongs to the bZIP family. Maf subfamily. (286 aa)
BCO2Beta-carotene oxygenase 2. (610 aa)
TYRP15,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. (536 aa)
EDNRBG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (560 aa)
MLANAMelan-A. (113 aa)
TYRTyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. (537 aa)
OCA2OCA2 melanosomal transmembrane protein. (726 aa)
SOX10Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. (461 aa)
SLC38A11Solute carrier family 38 member 11. (390 aa)
SLC24A4Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (528 aa)
TRPM1Transient receptor potential cation channel subfamily M member 1. (1625 aa)
SYPMARVEL domain-containing protein. (338 aa)
SLC45A2Uncharacterized protein. (543 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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