(7 nodes) (2022) TBHQ alleviates pyroptosis and necroptosis in chicken alveolar epithelial cells induced by fine particulate matter from broiler houses. network (Gallus gallus)

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Your Input:
	MLKL	Mixed lineage kinase domain like pseudokinase. (486 aa)
	IL18	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. (198 aa)
	RIPK1	Uncharacterized protein. (682 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	ACTB	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
	CASP1	Uncharacterized protein; Belongs to the peptidase C14A family. (540 aa)
	RIPK3	Uncharacterized protein. (424 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	CASP1	ENSGALP00000060844	ENSGALP00000070056	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.652
ACTB	IL18	ENSGALP00000060844	ENSGALP00000012772	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	0.603
ACTB	IL1B	ENSGALP00000060844	ENSGALP00000050171	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Interleukin-1; Belongs to the IL-1 family.	0.861
ACTB	MLKL	ENSGALP00000060844	ENSGALP00000004360	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Mixed lineage kinase domain like pseudokinase.	0.408
CASP1	ACTB	ENSGALP00000070056	ENSGALP00000060844	Uncharacterized protein; Belongs to the peptidase C14A family.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.652
CASP1	IL18	ENSGALP00000070056	ENSGALP00000012772	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	0.998
CASP1	IL1B	ENSGALP00000070056	ENSGALP00000050171	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-1; Belongs to the IL-1 family.	0.998
CASP1	MLKL	ENSGALP00000070056	ENSGALP00000004360	Uncharacterized protein; Belongs to the peptidase C14A family.	Mixed lineage kinase domain like pseudokinase.	0.721
CASP1	RIPK1	ENSGALP00000070056	ENSGALP00000036418	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.592
CASP1	RIPK3	ENSGALP00000070056	ENSGALP00000071292	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.734
IL18	ACTB	ENSGALP00000012772	ENSGALP00000060844	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.603
IL18	CASP1	ENSGALP00000012772	ENSGALP00000070056	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.998
IL18	IL1B	ENSGALP00000012772	ENSGALP00000050171	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	Interleukin-1; Belongs to the IL-1 family.	0.983
IL18	MLKL	ENSGALP00000012772	ENSGALP00000004360	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	Mixed lineage kinase domain like pseudokinase.	0.406
IL1B	ACTB	ENSGALP00000050171	ENSGALP00000060844	Interleukin-1; Belongs to the IL-1 family.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.861
IL1B	CASP1	ENSGALP00000050171	ENSGALP00000070056	Interleukin-1; Belongs to the IL-1 family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.998
IL1B	IL18	ENSGALP00000050171	ENSGALP00000012772	Interleukin-1; Belongs to the IL-1 family.	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	0.983
IL1B	MLKL	ENSGALP00000050171	ENSGALP00000004360	Interleukin-1; Belongs to the IL-1 family.	Mixed lineage kinase domain like pseudokinase.	0.565
IL1B	RIPK1	ENSGALP00000050171	ENSGALP00000036418	Interleukin-1; Belongs to the IL-1 family.	Uncharacterized protein.	0.486
IL1B	RIPK3	ENSGALP00000050171	ENSGALP00000071292	Interleukin-1; Belongs to the IL-1 family.	Uncharacterized protein.	0.562