(9 nodes) (2021) The Advance of CRISPR-Cas9-Based and NIRCRISPR-Cas9-Based Imaging System. network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLK1	Serine/threonine-protein kinase PLK. (595 aa)
	LIG4	DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. (912 aa)
	BRCA2	Tower domain-containing protein. (3397 aa)
	XRCC6	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...] (647 aa)
	PRKDC	DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act a [...] (4132 aa)
	BRCA1	Uncharacterized protein. (1749 aa)
	CAMK2A	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (489 aa)
	PALB2	Partner and localizer of BRCA2. (1341 aa)
	EXO1	Uncharacterized protein. (800 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	BRCA2	ENSGALP00000004383	ENSGALP00000027524	Uncharacterized protein.	Tower domain-containing protein.	0.999
BRCA1	EXO1	ENSGALP00000004383	ENSGALP00000017465	Uncharacterized protein.	Uncharacterized protein.	0.969
BRCA1	LIG4	ENSGALP00000004383	ENSGALP00000027179	Uncharacterized protein.	DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination.	0.837
BRCA1	PALB2	ENSGALP00000004383	ENSGALP00000009796	Uncharacterized protein.	Partner and localizer of BRCA2.	0.999
BRCA1	PLK1	ENSGALP00000004383	ENSGALP00000009850	Uncharacterized protein.	Serine/threonine-protein kinase PLK.	0.860
BRCA1	PRKDC	ENSGALP00000004383	ENSGALP00000059070	Uncharacterized protein.	DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act a [...]	0.880
BRCA1	XRCC6	ENSGALP00000004383	ENSGALP00000053314	Uncharacterized protein.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...]	0.903
BRCA2	BRCA1	ENSGALP00000027524	ENSGALP00000004383	Tower domain-containing protein.	Uncharacterized protein.	0.999
BRCA2	EXO1	ENSGALP00000027524	ENSGALP00000017465	Tower domain-containing protein.	Uncharacterized protein.	0.967
BRCA2	LIG4	ENSGALP00000027524	ENSGALP00000027179	Tower domain-containing protein.	DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination.	0.880
BRCA2	PALB2	ENSGALP00000027524	ENSGALP00000009796	Tower domain-containing protein.	Partner and localizer of BRCA2.	0.999
BRCA2	PLK1	ENSGALP00000027524	ENSGALP00000009850	Tower domain-containing protein.	Serine/threonine-protein kinase PLK.	0.966
BRCA2	PRKDC	ENSGALP00000027524	ENSGALP00000059070	Tower domain-containing protein.	DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act a [...]	0.859
BRCA2	XRCC6	ENSGALP00000027524	ENSGALP00000053314	Tower domain-containing protein.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...]	0.862
EXO1	BRCA1	ENSGALP00000017465	ENSGALP00000004383	Uncharacterized protein.	Uncharacterized protein.	0.969
EXO1	BRCA2	ENSGALP00000017465	ENSGALP00000027524	Uncharacterized protein.	Tower domain-containing protein.	0.967
EXO1	LIG4	ENSGALP00000017465	ENSGALP00000027179	Uncharacterized protein.	DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination.	0.925
EXO1	PALB2	ENSGALP00000017465	ENSGALP00000009796	Uncharacterized protein.	Partner and localizer of BRCA2.	0.919
EXO1	PLK1	ENSGALP00000017465	ENSGALP00000009850	Uncharacterized protein.	Serine/threonine-protein kinase PLK.	0.739
EXO1	PRKDC	ENSGALP00000017465	ENSGALP00000059070	Uncharacterized protein.	DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act a [...]	0.885