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ESR2 | Estrogen receptor beta; Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Belongs to the nuclear hormone receptor family. NR3 subfamily. (472 aa) | ||||
GLB1L | Galactosidase beta 1 like; Belongs to the glycosyl hydrolase 35 family. (633 aa) | ||||
AKR1A1 | Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids. Acts as an aldehyde-detoxification enzyme (By similarity). Displays no reductase activity towards retinoids (By similarity). (365 aa) | ||||
CCND1 | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). (292 aa) | ||||
ABCC1 | Multidrug resistance-associated protein 1; Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency (By similarity); Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. (1524 aa) | ||||
INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa) | ||||
CYP2C23b | Cytochrome P450 2H2; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (491 aa) | ||||
CYP3A4 | Uncharacterized protein; Belongs to the cytochrome P450 family. (540 aa) | ||||
UGT1A1 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (532 aa) | ||||
GPER1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa) | ||||
CYP1A2 | Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa) | ||||
CDH1 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha- E/beta-7. (887 aa) | ||||
STC1 | Stanniocalcin 1. (247 aa) | ||||
ACHE | Acetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft; Belongs to the type-B carboxylesterase/lipase family. (767 aa) | ||||
ESR1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (651 aa) | ||||
FIGLA | BHLH domain-containing protein. (156 aa) | ||||
VASP | WH1 domain-containing protein. (91 aa) | ||||
BCHE | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (603 aa) | ||||
CD36 | Uncharacterized protein; Belongs to the CD36 family. (471 aa) | ||||
HDAC7 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1250 aa) | ||||
PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (498 aa) | ||||
CYP19A1 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (502 aa) | ||||
CBR3 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (276 aa) | ||||
GLB1L2 | Beta-galactosidase. (656 aa) | ||||
CSK | Tyrosine-protein kinase CSK; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C- terminal tails of Src-family kinases (SFKs). Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma mem [...] (450 aa) | ||||
GLB1 | Beta-galactosidase. (652 aa) | ||||
IGFBP1 | Uncharacterized protein. (269 aa) | ||||
ABCG2 | ATP-binding cassette sub-family G member 2. (701 aa) | ||||
COL3A1 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa) | ||||
ABCB1 | ATP binding cassette subfamily B member 1. (1293 aa) | ||||
IL1B | Interleukin-1; Belongs to the IL-1 family. (267 aa) | ||||
SCT | Secretin. (157 aa) | ||||
AR | Uncharacterized protein. (703 aa) | ||||
CCK | Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes. (130 aa) | ||||
CYP2C23a | Cytochrome P450 2H1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (491 aa) | ||||
CYP1A1 | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa) | ||||
ABCB1-2 | Multidrug resistance protein 1. (1288 aa) | ||||
TYR | Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. (537 aa) | ||||
PGR | Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (787 aa) | ||||
FLT1 | Vascular endothelial growth factor receptor 1; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the regulation of angiogenesis, cell survival, cell migration, macrophage function, and chemotaxis. Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the c [...] (1327 aa) | ||||
AKR1B10 | Aldo-keto reductase. (317 aa) | ||||
AKR1B1 | Aldo_ket_red domain-containing protein. (331 aa) | ||||
UGT2A1 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa) | ||||
NR1H4 | Farnesoid X receptor. (473 aa) |