STRINGSTRING
SNAP25 SNAP25 NPY NPY NPFFR2 NPFFR2 SIM1 SIM1 PNOC PNOC ALB ALB OTX2 OTX2 SOX2 SOX2 EN2 EN2 SMO SMO SOX1 SOX1 TH TH EMX1 EMX1 GAD1 GAD1 FOXG1 FOXG1 GAD2 GAD2 NKX2-1 NKX2-1 CARTPT CARTPT SLC17A6 SLC17A6 ACTB ACTB POMC POMC ENSGALP00000070006 ENSGALP00000070006 PAX6 PAX6 BDNF BDNF HUC HUC AGRP AGRP GDNF GDNF LEUTX LEUTX NPFFR1 NPFFR1 SHH SHH SYP SYP SST SST
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNAP25Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion (By similarity). Belongs to the SNAP-25 family. (206 aa)
NPYC-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa)
NPFFR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (422 aa)
SIM1SIM bHLH transcription factor 1. (766 aa)
PNOCUncharacterized protein. (194 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. (565 aa)
OTX2Homeodomain transcription factor. (289 aa)
SOX2Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa)
EN2Homeobox protein engrailed-2. (289 aa)
SMOSmoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa)
SOX1Transcription factor SOX-1; Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural protein and suppresses neuronal differentiation. (373 aa)
THTyrosine hydroxylase. (491 aa)
EMX1Empty spiracles homeobox 1. (235 aa)
GAD1Glutamate decarboxylase 67. (590 aa)
FOXG1Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. (451 aa)
GAD2Glutamate decarboxylase 2. (807 aa)
NKX2-1Homeobox domain-containing protein. (345 aa)
CARTPTCART prepropeptide. (111 aa)
SLC17A6MFS domain-containing protein. (585 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
POMCUncharacterized protein. (251 aa)
ENSGALP00000070006Synaptophysin. (351 aa)
PAX6Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development. (500 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (254 aa)
HUCRRM domain-containing protein. (124 aa)
AGRPAgouti-related protein. (233 aa)
GDNFGlial cell derived neurotrophic factor. (209 aa)
LEUTXHomeobox domain-containing protein. (403 aa)
NPFFR1Neuropeptide FF receptor 1; Belongs to the G-protein coupled receptor 1 family. (399 aa)
SHHSonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa)
SYPMARVEL domain-containing protein. (338 aa)
SSTSomatostatin-14; Somatostatin inhibits the release of somatotropin. (116 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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