STRINGSTRING
CYCS CYCS GPX7 GPX7 PRKCE PRKCE CYLD CYLD FGG FGG CCND1 CCND1 INS INS MTOR MTOR STAT5A STAT5A TRADD TRADD CYB5B CYB5B CDC27 CDC27 AXIN1 AXIN1 MYC MYC CD8A-3 CD8A-3 GPX4 GPX4 MMP9 MMP9 PPARG PPARG CD8A-2 CD8A-2 SMAD3 SMAD3 IGF1R IGF1R IGFBP3 IGFBP3 PTGS2 PTGS2 STAT4 STAT4 BCL2L1 BCL2L1 EGFR EGFR STAT2 STAT2 MAOB MAOB CHUK CHUK IL1B IL1B SCT SCT STAT1 STAT1 EGF EGF GPX1 GPX1 NFKBIA NFKBIA GPX8 GPX8 TIMP3 TIMP3 FGB FGB HMOX1 HMOX1 RIPK1 RIPK1 CD86 CD86 IL17A IL17A ACE2 ACE2 MAOA MAOA CD80 CD80 CYB5A CYB5A BCL2 BCL2 TAB2 TAB2 SOD2 SOD2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (210 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (743 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (941 aa)
FGGFibrinogen C-terminal domain-containing protein. (438 aa)
CCND1G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). (292 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
STAT5ASignal transducer and activator of transcription. (764 aa)
TRADDTNFRSF1A associated via death domain. (461 aa)
CYB5BCytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (144 aa)
CDC27Uncharacterized protein. (833 aa)
AXIN1Axin-1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (841 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa)
CD8A-3Ig-like domain-containing protein. (318 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
MMP9Uncharacterized protein. (713 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (498 aa)
CD8A-2Ig-like domain-containing protein. (235 aa)
SMAD3Mothers against decapentaplegic homolog 3; Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor- regulated SMAD (R-SMAD) (By similarity). (426 aa)
IGF1RTyrosine-protein kinase receptor. (1363 aa)
IGFBP3Uncharacterized protein. (337 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (652 aa)
STAT4Signal transducer and activator of transcription. (749 aa)
BCL2L1Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity). (229 aa)
EGFREpidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...] (1226 aa)
STAT2Signal transducer and activator of transcription. (961 aa)
MAOBAmine oxidase. (521 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (724 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
SCTSecretin. (157 aa)
STAT1Signal transducer and activator of transcription. (755 aa)
EGFUncharacterized protein. (1283 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (182 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity). (318 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (210 aa)
TIMP3Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli; Belongs to the protease inhibitor I35 (TIMP) family. (212 aa)
FGBFibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. (488 aa)
HMOX1Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. (317 aa)
RIPK1Uncharacterized protein. (682 aa)
CD86Uncharacterized protein. (319 aa)
IL17AUncharacterized protein. (169 aa)
ACE2Angiotensin-converting enzyme. (808 aa)
MAOAAmine oxidase. (532 aa)
CD80Uncharacterized protein. (316 aa)
CYB5ACytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. (138 aa)
BCL2Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (697 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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