26 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CYP1A2	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
	ANGPTL4	Angiopoietin like 4. (478 aa)
	STAT5A	Signal transducer and activator of transcription. (764 aa)
	CYP3A4	Uncharacterized protein; Belongs to the cytochrome P450 family. (540 aa)
	TXNIP	Thioredoxin interacting protein. (430 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (881 aa)
	PPARD	Uncharacterized protein. (545 aa)
	NR1H3	Uncharacterized protein. (519 aa)
	ADIPOQ	C1q domain-containing protein. (244 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (643 aa)
	PNPLA3	Patatin like phospholipase domain containing 3. (543 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (498 aa)
	SLCO1B3	Solute carrier organic anion transporter family member. (722 aa)
	HNF1A	Hepatocyte nuclear factor 1-alpha; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. May participate in the control of the hormone-dependent expression of the lysozyme gene in the oviduct and liver. In liver it could repress the gene while in oviduct it may act as an activator. Belongs to the HNF1 homeobox family. (634 aa)
	STAT4	Signal transducer and activator of transcription. (749 aa)
	CYP7A1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (513 aa)
	STAT2	Signal transducer and activator of transcription. (961 aa)
	RXRA	Retinoid X receptor alpha. (467 aa)
	STAT1	Signal transducer and activator of transcription. (755 aa)
	NFKBIA	NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity). (318 aa)
	HMOX1	Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. (317 aa)
	GCLC	Glutamate-cysteine ligase catalytic subunit. (636 aa)
	ABCG1	ATP binding cassette subfamily G member 1. (666 aa)
	ABCA1	Uncharacterized protein. (2260 aa)
	NR1H4	Farnesoid X receptor. (473 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	ABCG1	ENSGALP00000024845	ENSGALP00000025999	Uncharacterized protein.	ATP binding cassette subfamily G member 1.	0.483
ABCA1	CYP7A1	ENSGALP00000024845	ENSGALP00000054104	Uncharacterized protein.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.578
ABCA1	INS	ENSGALP00000024845	ENSGALP00000010567	Uncharacterized protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.469
ABCA1	NR1H3	ENSGALP00000024845	ENSGALP00000073715	Uncharacterized protein.	Uncharacterized protein.	0.861
ABCA1	PCSK9	ENSGALP00000024845	ENSGALP00000071049	Uncharacterized protein.	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family.	0.523
ABCA1	PPARG	ENSGALP00000024845	ENSGALP00000067699	Uncharacterized protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.615
ABCG1	ABCA1	ENSGALP00000025999	ENSGALP00000024845	ATP binding cassette subfamily G member 1.	Uncharacterized protein.	0.483
ABCG1	CYP7A1	ENSGALP00000025999	ENSGALP00000054104	ATP binding cassette subfamily G member 1.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.434
ABCG1	INS	ENSGALP00000025999	ENSGALP00000010567	ATP binding cassette subfamily G member 1.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.410
ABCG1	NR1H3	ENSGALP00000025999	ENSGALP00000073715	ATP binding cassette subfamily G member 1.	Uncharacterized protein.	0.770
ABCG1	PPARG	ENSGALP00000025999	ENSGALP00000067699	ATP binding cassette subfamily G member 1.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.405
ADIPOQ	INS	ENSGALP00000008899	ENSGALP00000010567	C1q domain-containing protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.958
ADIPOQ	NR1H4	ENSGALP00000008899	ENSGALP00000018906	C1q domain-containing protein.	Farnesoid X receptor.	0.485
ADIPOQ	PNPLA3	ENSGALP00000008899	ENSGALP00000069032	C1q domain-containing protein.	Patatin like phospholipase domain containing 3.	0.480
ADIPOQ	PPARD	ENSGALP00000008899	ENSGALP00000072840	C1q domain-containing protein.	Uncharacterized protein.	0.519
ADIPOQ	PPARG	ENSGALP00000008899	ENSGALP00000067699	C1q domain-containing protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.899
ADIPOQ	SIRT1	ENSGALP00000008899	ENSGALP00000004350	C1q domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.681
ANGPTL4	PPARD	ENSGALP00000000875	ENSGALP00000072840	Angiopoietin like 4.	Uncharacterized protein.	0.447
ANGPTL4	PPARG	ENSGALP00000000875	ENSGALP00000067699	Angiopoietin like 4.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.644
CYP1A2	CYP3A4	ENSGALP00000002016	ENSGALP00000007048	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.966