(30 nodes) (2022) Immunogenic Cell Death, DAMPs and Prothymosin alpha as a Putative Anticancer Immune Response Biomarker. network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	RIPK3	Uncharacterized protein. (424 aa)
	HMGB1	High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Can restructure the canonical nucleosome. Proposed to be an universal biosensor for nucle [...] (215 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (418 aa)
	MLKL	Mixed lineage kinase domain like pseudokinase. (486 aa)
	CALR3	Calreticulin. (420 aa)
	LOC101748744	Serine protease; Belongs to the peptidase S1B family. (363 aa)
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
	IL18	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. (198 aa)
	CASP8	Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
	CREB1	cAMP response element-binding protein. (327 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (309 aa)
	CYCS	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	HISTH1	Histone H1; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (305 aa)
	IL2	Interleukin; Belongs to the IL-15/IL-21 family. (143 aa)
	BCL2	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
	PARP1	Poly [ADP-ribose] polymerase 1; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Also mediates serine ADP-ribosylation of target proteins following interaction with HP [...] (1011 aa)
	TLR2B	Toll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (781 aa)
	ENDOG	Endonuclease G. (201 aa)
	CALR	Calreticulin. (416 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	TLR2A	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (955 aa)
	HTRA2	HtrA serine peptidase 2. (200 aa)
	CREBBP	CREB binding protein. (2522 aa)
	ANXA5	Annexin A5; Collagen-binding protein. (321 aa)
	CD8A-2	Ig-like domain-containing protein. (235 aa)
	CASP18	Initiator caspase; Belongs to the peptidase C14A family. (464 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (283 aa)
	CASP1	Uncharacterized protein; Belongs to the peptidase C14A family. (540 aa)
	CD8A-3	Ig-like domain-containing protein. (318 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA5	APAF1	ENSGALP00000055261	ENSGALP00000037437	Annexin A5; Collagen-binding protein.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.558
ANXA5	BCL2	ENSGALP00000055261	ENSGALP00000020984	Annexin A5; Collagen-binding protein.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.876
ANXA5	CALR	ENSGALP00000055261	ENSGALP00000046274	Annexin A5; Collagen-binding protein.	Calreticulin.	0.535
ANXA5	CALR3	ENSGALP00000055261	ENSGALP00000006222	Annexin A5; Collagen-binding protein.	Calreticulin.	0.522
ANXA5	CASP18	ENSGALP00000055261	ENSGALP00000065273	Annexin A5; Collagen-binding protein.	Initiator caspase; Belongs to the peptidase C14A family.	0.811
ANXA5	CASP3	ENSGALP00000055261	ENSGALP00000068843	Annexin A5; Collagen-binding protein.	Caspase-3; Belongs to the peptidase C14A family.	0.960
ANXA5	CASP7	ENSGALP00000055261	ENSGALP00000014503	Annexin A5; Collagen-binding protein.	Caspase 7; Belongs to the peptidase C14A family.	0.600
ANXA5	CASP8	ENSGALP00000055261	ENSGALP00000013591	Annexin A5; Collagen-binding protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.816
ANXA5	CASP9	ENSGALP00000055261	ENSGALP00000002083	Annexin A5; Collagen-binding protein.	Caspase 9; Belongs to the peptidase C14A family.	0.860
ANXA5	CD8A-2	ENSGALP00000055261	ENSGALP00000059832	Annexin A5; Collagen-binding protein.	Ig-like domain-containing protein.	0.785
ANXA5	CD8A-3	ENSGALP00000055261	ENSGALP00000071819	Annexin A5; Collagen-binding protein.	Ig-like domain-containing protein.	0.785
ANXA5	CYCS	ENSGALP00000055261	ENSGALP00000017934	Annexin A5; Collagen-binding protein.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.765
ANXA5	IL1B	ENSGALP00000055261	ENSGALP00000050171	Annexin A5; Collagen-binding protein.	Interleukin-1; Belongs to the IL-1 family.	0.654
ANXA5	PARP1	ENSGALP00000055261	ENSGALP00000038037	Annexin A5; Collagen-binding protein.	Poly [ADP-ribose] polymerase 1; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Also mediates serine ADP-ribosylation of target proteins following interaction with HP [...]	0.529
ANXA5	TLR4	ENSGALP00000055261	ENSGALP00000011319	Annexin A5; Collagen-binding protein.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.486
APAF1	ANXA5	ENSGALP00000037437	ENSGALP00000055261	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Annexin A5; Collagen-binding protein.	0.558
APAF1	BCL2	ENSGALP00000037437	ENSGALP00000020984	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.978
APAF1	CALR	ENSGALP00000037437	ENSGALP00000046274	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Calreticulin.	0.527
APAF1	CALR3	ENSGALP00000037437	ENSGALP00000006222	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Calreticulin.	0.527
APAF1	CASP1	ENSGALP00000037437	ENSGALP00000070056	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.786