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RIPK3 | Uncharacterized protein. (424 aa) | ||||
HMGB1 | High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Can restructure the canonical nucleosome. Proposed to be an universal biosensor for nucle [...] (215 aa) | ||||
CASP9 | Caspase 9; Belongs to the peptidase C14A family. (418 aa) | ||||
MLKL | Mixed lineage kinase domain like pseudokinase. (486 aa) | ||||
CALR3 | Calreticulin. (420 aa) | ||||
LOC101748744 | Serine protease; Belongs to the peptidase S1B family. (363 aa) | ||||
TLR4 | Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa) | ||||
IL18 | Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. (198 aa) | ||||
CASP8 | Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa) | ||||
CREB1 | cAMP response element-binding protein. (327 aa) | ||||
CASP7 | Caspase 7; Belongs to the peptidase C14A family. (309 aa) | ||||
CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) | ||||
HISTH1 | Histone H1; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (305 aa) | ||||
IL2 | Interleukin; Belongs to the IL-15/IL-21 family. (143 aa) | ||||
BCL2 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa) | ||||
APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa) | ||||
PARP1 | Poly [ADP-ribose] polymerase 1; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Also mediates serine ADP-ribosylation of target proteins following interaction with HP [...] (1011 aa) | ||||
TLR2B | Toll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (781 aa) | ||||
ENDOG | Endonuclease G. (201 aa) | ||||
CALR | Calreticulin. (416 aa) | ||||
IL1B | Interleukin-1; Belongs to the IL-1 family. (267 aa) | ||||
TLR2A | Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (955 aa) | ||||
HTRA2 | HtrA serine peptidase 2. (200 aa) | ||||
CREBBP | CREB binding protein. (2522 aa) | ||||
ANXA5 | Annexin A5; Collagen-binding protein. (321 aa) | ||||
CD8A-2 | Ig-like domain-containing protein. (235 aa) | ||||
CASP18 | Initiator caspase; Belongs to the peptidase C14A family. (464 aa) | ||||
CASP3 | Caspase-3; Belongs to the peptidase C14A family. (283 aa) | ||||
CASP1 | Uncharacterized protein; Belongs to the peptidase C14A family. (540 aa) | ||||
CD8A-3 | Ig-like domain-containing protein. (318 aa) |