STRINGSTRING
RIPK3 RIPK3 HMGB1 HMGB1 CASP9 CASP9 MLKL MLKL CALR3 CALR3 LOC101748744 LOC101748744 TLR4 TLR4 IL18 IL18 CASP8 CASP8 CREB1 CREB1 CASP7 CASP7 CYCS CYCS HISTH1 HISTH1 IL2 IL2 BCL2 BCL2 APAF1 APAF1 PARP1 PARP1 TLR2B TLR2B ENDOG ENDOG CALR CALR IL1B IL1B TLR2A TLR2A HTRA2 HTRA2 CREBBP CREBBP ANXA5 ANXA5 CD8A-2 CD8A-2 CASP18 CASP18 CASP3 CASP3 CASP1 CASP1 CD8A-3 CD8A-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RIPK3Uncharacterized protein. (424 aa)
HMGB1High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Can restructure the canonical nucleosome. Proposed to be an universal biosensor for nucle [...] (215 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (418 aa)
MLKLMixed lineage kinase domain like pseudokinase. (486 aa)
CALR3Calreticulin. (420 aa)
LOC101748744Serine protease; Belongs to the peptidase S1B family. (363 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
IL18Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. (198 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
CREB1cAMP response element-binding protein. (327 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (309 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
HISTH1Histone H1; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (305 aa)
IL2Interleukin; Belongs to the IL-15/IL-21 family. (143 aa)
BCL2Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
PARP1Poly [ADP-ribose] polymerase 1; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Also mediates serine ADP-ribosylation of target proteins following interaction with HP [...] (1011 aa)
TLR2BToll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (781 aa)
ENDOGEndonuclease G. (201 aa)
CALRCalreticulin. (416 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
TLR2AToll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (955 aa)
HTRA2HtrA serine peptidase 2. (200 aa)
CREBBPCREB binding protein. (2522 aa)
ANXA5Annexin A5; Collagen-binding protein. (321 aa)
CD8A-2Ig-like domain-containing protein. (235 aa)
CASP18Initiator caspase; Belongs to the peptidase C14A family. (464 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (283 aa)
CASP1Uncharacterized protein; Belongs to the peptidase C14A family. (540 aa)
CD8A-3Ig-like domain-containing protein. (318 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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