STRINGSTRING
CDK1 CDK1 STAT5A STAT5A CYP3A4 CYP3A4 CYP3A5 CYP3A5 ALDH3A2 ALDH3A2 ADIPOQ ADIPOQ ACOX2 ACOX2 PLA2G1B PLA2G1B DLAT DLAT COL4A5 COL4A5 PNLIPRP1 PNLIPRP1 MCM5 MCM5 ACOX3 ACOX3 MCM3 MCM3 NSDHL NSDHL MCM6 MCM6 AGXT AGXT PYGB PYGB CX3CL1 CX3CL1 ADIPOR2 ADIPOR2 STAT1 STAT1 DLD DLD MYH7 MYH7 INSR INSR CAMK1D CAMK1D SORD SORD COL3A1 COL3A1 GFPT2 GFPT2 STAT2 STAT2 FABP3 FABP3 CYP7A1 CYP7A1 FBP2 FBP2 STAT4 STAT4 CLPS CLPS PPP1R3B PPP1R3B ACAP3 ACAP3 HSD17B7 HSD17B7 CCNB3 CCNB3 AGRN AGRN ACTB ACTB ATP5B ATP5B COL6A6 COL6A6 COL6A3 COL6A3 FITM2 FITM2 THBS2 THBS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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CDK1Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle (By similarity). It is required in higher cells for entry into S-phase and mitosis (By similarity). p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). May play a role in regulating the amplitude of the cyclic expression of circadian clock genes (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (303 aa)
STAT5ASignal transducer and activator of transcription. (764 aa)
CYP3A4Uncharacterized protein; Belongs to the cytochrome P450 family. (540 aa)
CYP3A5Uncharacterized protein. (508 aa)
ALDH3A2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (490 aa)
ADIPOQC1q domain-containing protein. (244 aa)
ACOX2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (675 aa)
PLA2G1BPhospholipase A(2). (148 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (632 aa)
COL4A5Collagen IV NC1 domain-containing protein. (540 aa)
PNLIPRP1Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (467 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (706 aa)
MCM3DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (812 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (346 aa)
MCM6DNA helicase; Belongs to the MCM family. (825 aa)
AGXTAlanine--glyoxylate and serine--pyruvate aminotransferase. (473 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
CX3CL1SCY domain-containing protein. (496 aa)
ADIPOR2Uncharacterized protein. (386 aa)
STAT1Signal transducer and activator of transcription. (755 aa)
DLDDihydrolipoyl dehydrogenase. (508 aa)
MYH7Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1931 aa)
INSRTyrosine-protein kinase receptor. (1324 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID; Belongs to the protein kinase superfamily. (379 aa)
SORDSorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is active with D- sorbitol (D-glucitol) as substrate, leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism (By similarity). (355 aa)
COL3A1Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa)
GFPT2Glutamine-fructose-6-phosphate transaminase 2. (682 aa)
STAT2Signal transducer and activator of transcription. (961 aa)
FABP3Heart fatty acid binding protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (513 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (340 aa)
STAT4Signal transducer and activator of transcription. (749 aa)
CLPSColipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. (115 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (301 aa)
ACAP3ArfGAP with coiled-coil, ankyrin repeat and PH domains 3. (837 aa)
HSD17B7Uncharacterized protein. (332 aa)
CCNB3G2/mitotic-specific cyclin-B3; Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Could be involved at the G2/M (mitosis or meiosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. (403 aa)
AGRNAgrin C-terminal 110 kDa subunit; [Isoform 1]: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clu [...] (2076 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
ATP5BATP synthase subunit beta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...] (649 aa)
COL6A6Uncharacterized protein. (774 aa)
COL6A3Collagen alpha-3(VI) chain; Collagen VI acts as a cell-binding protein. (3215 aa)
FITM2Fat storage inducing transmembrane protein 2. (396 aa)
THBS2Thrombospondin-2; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions; Belongs to the thrombospondin family. (1213 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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