(23 nodes) (2022) High Mobility Group Proteins in Sepsis. network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	TLK1	Tousled like kinase 1. (870 aa)
	CASP1	Uncharacterized protein; Belongs to the peptidase C14A family. (540 aa)
	ATF3	Activating transcription factor 3. (181 aa)
	SQSTM1	Sequestosome 1. (453 aa)
	TLR2A	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (955 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	HMGN4	Non-histone chromosomal protein HMG-17; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation; Belongs to the HMGN family. (90 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (299 aa)
	TLR2B	Toll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (781 aa)
	HMOX1	Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. (317 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (283 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
	HMGA2	High mobility group protein I-C. (109 aa)
	CDK6	Cyclin-dependent kinase; Belongs to the protein kinase superfamily. (326 aa)
	TLR5	TLR5; Belongs to the Toll-like receptor family. (861 aa)
	HMGB3	High mobility group protein B3; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Binds to the delta-1 crystallin/ASL1 enhancer. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sens [...] (202 aa)
	IL18	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. (198 aa)
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
	F3	Coagulation factor III, tissue factor. (283 aa)
	STAT3	Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa)
	MLKL	Mixed lineage kinase domain like pseudokinase. (486 aa)
	RIPK1	Uncharacterized protein. (682 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF3	IL1B	ENSGALP00000074229	ENSGALP00000050171	Activating transcription factor 3.	Interleukin-1; Belongs to the IL-1 family.	0.488
ATF3	IL6	ENSGALP00000074229	ENSGALP00000068117	Activating transcription factor 3.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.563
ATF3	MYD88	ENSGALP00000074229	ENSGALP00000042597	Activating transcription factor 3.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.412
ATF3	STAT3	ENSGALP00000074229	ENSGALP00000005161	Activating transcription factor 3.	Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes.	0.586
CASP1	HMOX1	ENSGALP00000070056	ENSGALP00000036970	Uncharacterized protein; Belongs to the peptidase C14A family.	Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.	0.479
CASP1	IL18	ENSGALP00000070056	ENSGALP00000012772	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	0.998
CASP1	IL1B	ENSGALP00000070056	ENSGALP00000050171	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-1; Belongs to the IL-1 family.	0.998
CASP1	IL6	ENSGALP00000070056	ENSGALP00000068117	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.856
CASP1	MLKL	ENSGALP00000070056	ENSGALP00000004360	Uncharacterized protein; Belongs to the peptidase C14A family.	Mixed lineage kinase domain like pseudokinase.	0.721
CASP1	MYD88	ENSGALP00000070056	ENSGALP00000042597	Uncharacterized protein; Belongs to the peptidase C14A family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.823
CASP1	RIPK1	ENSGALP00000070056	ENSGALP00000036418	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.592
CASP1	STAT3	ENSGALP00000070056	ENSGALP00000005161	Uncharacterized protein; Belongs to the peptidase C14A family.	Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes.	0.503
CASP1	TLR2A	ENSGALP00000070056	ENSGALP00000050968	Uncharacterized protein; Belongs to the peptidase C14A family.	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).	0.759
CASP1	TLR2B	ENSGALP00000070056	ENSGALP00000038134	Uncharacterized protein; Belongs to the peptidase C14A family.	Toll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).	0.758
CASP1	TLR3	ENSGALP00000070056	ENSGALP00000021914	Uncharacterized protein; Belongs to the peptidase C14A family.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.750
CASP1	TLR4	ENSGALP00000070056	ENSGALP00000011319	Uncharacterized protein; Belongs to the peptidase C14A family.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.825
CASP1	TLR5	ENSGALP00000070056	ENSGALP00000015286	Uncharacterized protein; Belongs to the peptidase C14A family.	TLR5; Belongs to the Toll-like receptor family.	0.577
CASP3	CDK6	ENSGALP00000068843	ENSGALP00000015412	Caspase-3; Belongs to the peptidase C14A family.	Cyclin-dependent kinase; Belongs to the protein kinase superfamily.	0.717
CASP3	HMOX1	ENSGALP00000068843	ENSGALP00000036970	Caspase-3; Belongs to the peptidase C14A family.	Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.	0.770
CASP3	IL18	ENSGALP00000068843	ENSGALP00000012772	Caspase-3; Belongs to the peptidase C14A family.	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	0.647